School of Chemical Engineering, University of Campinas (UNICAMP), 13083-852, Campinas, SP, Brazil.
Department of Chemical Engineering and Food Engineering, Federal University of Santa Catarina (UFSC), 88040-900, Florianópolis, SC, Brazil.
Adv Colloid Interface Sci. 2022 Feb;300:102582. doi: 10.1016/j.cis.2021.102582. Epub 2021 Dec 14.
Nanoparticles have emerged as promising drug delivery systems for the treatment of several diseases. Novel cancer therapies have exploited these particles as alternative adjuvant therapies to overcome the traditional limitations of radio and chemotherapy. Curcumin is a natural bioactive compound found in turmeric, that has been reported to show anticancer activity against several types of tumors. Despite some biological limitations regarding its absorption in the human body, curcumin encapsulation in poly(lactic-co-glycolic acid) (PLGA), a non-toxic, biodegradable and biocompatible polymer, represents an effective strategy to deliver a drug to a tumor site. Furthermore, PLGA nanoparticles can be engineered with targeting moieties to reach specific cancer cells, thus enhancing the antitumor effects of curcumin. We herein aim to bring an up-to-date summary of the recently developed strategies for curcumin delivery to different types of cancer cells through encapsulation in PLGA nanoparticles, correlating their effects with those of curcumin on the biological capabilities acquired by cancer cells (cancer hallmarks). We discuss the targeting strategies proposed for advanced curcumin delivery and the respective improvements achieved for each cancer cell analyzed, in addition to exploring the encapsulation techniques employed. The conjugation of correct encapsulation techniques with tumor-oriented targeting design can result in curcumin-loaded PLGA nanoparticles that can successfully integrate the elaborate network of development of alternative cancer treatments along with traditional ones. Finally, the current challenges and future demands to launch these nanoparticles in oncology are comprehensively examined.
纳米颗粒已成为治疗多种疾病的有前途的药物输送系统。新型癌症疗法利用这些颗粒作为辅助治疗方法，以克服放射和化学疗法的传统局限性。姜黄素是姜黄中发现的一种天然生物活性化合物，据报道它对几种类型的肿瘤具有抗癌活性。尽管其在人体中的吸收存在一些生物学限制，但将姜黄素封装在聚（乳酸-共-乙醇酸）（PLGA）中，一种无毒、可生物降解和生物相容的聚合物，是将药物递送到肿瘤部位的有效策略。此外，PLGA 纳米颗粒可以通过靶向部分进行工程设计，以到达特定的癌细胞，从而增强姜黄素的抗肿瘤作用。我们旨在对最近开发的通过将姜黄素封装在 PLGA 纳米颗粒中递送到不同类型癌细胞的策略进行最新总结，将其效果与姜黄素对癌细胞获得的生物学特性（癌症标志）的效果相关联。我们讨论了用于先进姜黄素递送的靶向策略，以及针对每种分析的癌细胞所取得的各自改进，此外还探讨了所采用的封装技术。将正确的封装技术与肿瘤导向的靶向设计相结合，可以得到载有姜黄素的 PLGA 纳米颗粒，这些纳米颗粒可以成功地将替代癌症治疗的精心设计的网络与传统治疗方法结合起来。最后，全面研究了将这些纳米颗粒推向肿瘤学领域所面临的当前挑战和未来需求。
