Yang Zhenqi, Yin Guoyong, Sun Shuyang, Xu Ping
State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P.R. China.
Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
iScience. 2024 Dec 1;27(12):111512. doi: 10.1016/j.isci.2024.111512. eCollection 2024 Dec 20.
Polylactic acid (PLA) is a biodegradable and bio-based polymer that has gained significant attention as an environmentally friendly alternative to traditional petroleum-based plastics. In clinical treatment, biocompatible and non-toxic PLA materials enhance safety and reduce tissue reactions, while the biodegradability allows it to breakdown over time naturally, avoiding a second surgery. With the emergence of nanotechnology and three-dimensional (3D) printing, medical utilized-PLA has been produced with more structural and biological properties at both micro and macro scales for clinical therapy. This review summarizes current applications of the PLA-based biomaterials in drug delivery systems, orthopedic treatment, tissue regenerative engineering, and surgery and medical devices, providing viewpoints regarding the prospective medical utilization.
聚乳酸（PLA）是一种可生物降解的生物基聚合物，作为传统石油基塑料的环保替代品而备受关注。在临床治疗中，生物相容性和无毒的PLA材料可提高安全性并减少组织反应，而其生物可降解性使其能够随时间自然分解，避免了二次手术。随着纳米技术和三维（3D）打印的出现，已生产出在微观和宏观尺度上具有更多结构和生物学特性的医用PLA，用于临床治疗。本文综述了基于PLA的生物材料在药物递送系统、骨科治疗、组织再生工程以及手术和医疗器械中的当前应用，并对其未来的医学应用前景提出了观点。
