State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu, 215123, China.
State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu, 215123, China.
Biomaterials. 2022 Jan;280:121326. doi: 10.1016/j.biomaterials.2021.121326. Epub 2021 Dec 17.
Oxygen (O) is the substance irreplaceable of the body's metabolism, which is not only the primary consumable of life activities, but also provide the input energy for the whole body. Importantly, the O supply will act as an important role in the field of tumor theranostics. Herein, we successfully construct a radioactive nano-oxygen generator (Lu-APPs-PEG) with superior properties, which can not only realize a high-performance radioisotope labelling, but also unfreeze the limitation of O dependence of internal radioisotope therapy (IRT). More importantly, such nano-oxygen generator also can effectively enhance the infiltration of cytotoxic T cells (CTLs) in distant tumors and reduce tumor metastasis. Meanwhile, the increase of O in tumor-site can affect the metabolism of tumor cells and regulatory T (Treg) cells to reduce cancer cells proliferation by down-regulating the expression of hypoxia-inducible factor-1α (HIF-1α) and c-Myc. In short, the strategies we designed provide a new idea for the influence of nano-enzymes on tumor metabolism and immunotherapy.
氧气（O）是机体代谢不可替代的物质，不仅是生命活动的首要消耗物，而且为全身提供输入能量。重要的是，O 供应将在肿瘤治疗学领域发挥重要作用。在此，我们成功构建了一种具有优越性能的放射性纳米氧发生器（Lu-APPs-PEG），不仅可以实现高性能放射性同位素标记，而且还可以解除内部放射性同位素治疗（IRT）对 O 依赖的限制。更重要的是，这种纳米氧发生器还可以有效增强远处肿瘤中细胞毒性 T 细胞（CTLs）的浸润，并减少肿瘤转移。同时，肿瘤部位 O 的增加会影响肿瘤细胞和调节性 T（Treg）细胞的代谢，通过下调缺氧诱导因子-1α（HIF-1α）和 c-Myc 的表达来减少癌细胞增殖。简而言之，我们设计的策略为纳米酶对肿瘤代谢和免疫治疗的影响提供了新的思路。
