2020 年 12 月至 2021 年 10 月期间芬兰医护人员中 COVID-19 疫苗有效性的队列研究。

Infectious Disease Control and Vaccinations Unit, Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.

Population Health Unit, Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Tampere, Finland.

Vaccine. 2022 Jan 31;40(5):701-705. doi: 10.1016/j.vaccine.2021.12.032. Epub 2021 Dec 18.

Recently, Covid-19 vaccine effectiveness has decreased especially against mild disease due to emergence of the Delta variant and waning protection. In this register-based study among healthcare workers in Finland, the vaccine effectiveness of two-dose mRNA vaccine series against SARS-CoV-2 infection decreased from 82% (95% CI 79-85%) 14-90 days after vaccination to 53% (43-62%) after 6 months. Similar trend was observed for other series. Waning was not observed against Covid-19 hospitalization. These results facilitate decision-making of booster doses for healthcare workers.

最近，由于 Delta 变异株的出现和保护效力的下降，Covid-19 疫苗的有效性，尤其是针对轻症疾病的有效性已经下降。在这项针对芬兰医护人员的基于登记的研究中，两剂 mRNA 疫苗系列对 SARS-CoV-2 感染的疫苗效力在接种后 14-90 天从 82%（95%CI 79-85%）下降到 6 个月后的 53%（43-62%）。其他系列也观察到了类似的趋势。对于 Covid-19 住院治疗，没有观察到疫苗效力下降的情况。这些结果为医护人员接种加强针的决策提供了依据。