Division of Neonatology and Pulmonary Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Center for Lung Regenerative Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Semin Fetal Neonatal Med. 2022 Feb;27(1):101322. doi: 10.1016/j.siny.2021.101322. Epub 2021 Dec 20.
Neonatal diseases such as hypoxic ischemic encephalopathy, diseases of prematurity and congenital disorders carry increased morbidity and mortality. Despite technological advancements, their incidence remains largely unabated. Stem cell (SC) interventions are novel therapies in the neonatal world. In pre-clinical models of neonatal diseases, SC applications have shown encouraging results. SC sources vary, with the bone marrow being the most utilized. However, the ability to harvest bone marrow SCs from neonates is limited. Placental-tissue derived SCs (PTSCs), provide an alternative and highly attractive source. Human placentas, the cornerstone of fetal survival, are abundant with such cells. Comparing to adult pools, PTSCs exhibit increased potency, decreased immunogenicity and stronger anti-inflammatory effects. Several types of PTSCs have been identified, with mesenchymal stem cells being the most utilized population. This review will focus on PTSCs and their pre-clinical and clinical applications in neonatology.
新生儿疾病（如缺氧缺血性脑病、早产儿疾病和先天性疾病）具有较高的发病率和死亡率。尽管技术不断进步，但这些疾病的发病率仍基本没有下降。干细胞（SC）干预是新生儿领域的新型治疗方法。在新生儿疾病的临床前模型中，SC 应用已显示出令人鼓舞的结果。SC 的来源多种多样，骨髓是最常用的来源。然而，从新生儿中采集骨髓 SC 的能力有限。胎盘组织衍生的干细胞（PTSC）提供了一种替代的、极具吸引力的来源。胎盘是胎儿生存的基石，其中含有丰富的此类细胞。与成人池相比，PTSC 表现出更高的效力、更低的免疫原性和更强的抗炎作用。已经确定了几种类型的 PTSC，其中间充质干细胞是最常用的群体。这篇综述将重点介绍 PTSC 及其在新生儿学中的临床前和临床应用。
