Applied Physiology & Nutrition Research Group, University of São Paulo, Sao Paulo, Brazil; Food Research Center, University of São Paulo, Sao Paulo, Brazil.
Applied Physiology & Nutrition Research Group, University of São Paulo, Sao Paulo, Brazil.
Brain Behav Immun. 2022 Mar;101:49-56. doi: 10.1016/j.bbi.2021.12.016. Epub 2021 Dec 23.
To investigate whether physical activity is associated with enhanced immunogenicity of a SARS-CoV-2 inactivated vaccine (Coronavac) in patients with autoimmune rheumatic diseases (ARD) (n = 898) and in non-ARD (n = 197) individuals without pre-existing immunogenicity to SARS-CoV-2.
This was a prospective cohort study within an open-label, single-arm, phase 4 vaccination trial. Immunogenicity was assessed after vaccination by measuring seroconversion rates of total anti-SARS-CoV-2 S1/S2 IgG (SC), geometric mean titers of anti-S1/S2 IgG (GMT), factor-increase in GMT (FI-GMT), frequency of neutralizing antibody (NAb), and median neutralizing activity. Physical activity (active being defined as ≥ 150 min/week) and sedentary behavior (>8h/day) were assessed by questionnaire.
Physically active ARD patients (n = 494) were younger and less frequently used prednisone/biologics than inactive patients (n = 404). After controlling for covariates, active patients exhibited greater SC (OR: 1.4 [95%CI: 1.1-2.0]), GMT (32% [95%CI: 8.8-60) and FI-GMT (33% [95%CI: 9.6-63%]) vs. inactive. Cluster analysis (physical activity/sedentary status) revealed greater GMT (43.0% [95% CI: 11.0-84.0%) and FI-GMT (48.0% [95%CI: 14.0-92.0%]) in active/non-sedentary vs. inactive/sedentary ARD patients. A dose-response was observed, with greater benefits for the group of patients performing ≥ 350 min/week of physical activity (OR: 1.6 [95%CI: 1.1-2.4]; 41% [95%CI: 10-80%]; 35% [95%CI: 4.3-74], for SC, GMT, and FI-GMT, respectively) vs. the least active group (≤30 min/week). Greater SC (OR: 9.9 [95%CI: 1.1-89.0]) and GMT (26% [95%CI: 2.2-56.0%]) were observed in active vs. inactive non-ARD.
A physically active lifestyle may enhance SARS-CoV-2 vaccine immunogenicity, a finding of particular clinical relevance for immunocompromised patients.
Clinicaltrials.gov #NCT04754698.
研究身体活动是否与增强 SARS-CoV-2 灭活疫苗（科兴疫苗）在自身免疫性风湿病（ARD）患者（n=898）和无 SARS-CoV-2 预先免疫的非 ARD 个体（n=197）中的免疫原性相关。
这是一项在开放标签、单臂、4 期疫苗接种试验中的前瞻性队列研究。通过测量总抗 SARS-CoV-2 S1/S2 IgG（SC）的血清转化率、抗 S1/S2 IgG 的几何平均滴度（GMT）、GMT 的因子增加（FI-GMT）、中和抗体（NAb）的频率和中位数中和活性来评估接种后的免疫原性。通过问卷评估身体活动（活动定义为每周≥150 分钟）和久坐行为（>8 小时/天）。
与不活动患者（n=404）相比，活跃的 ARD 患者（n=494）年龄较小，且较少使用泼尼松/生物制剂。在控制了混杂因素后，与不活动患者相比，活跃患者的 SC（比值比：1.4[95%CI：1.1-2.0]）、GMT（32%[95%CI：8.8-60]）和 FI-GMT（33%[95%CI：9.6-63%]）更高。聚类分析（身体活动/久坐状态）显示，与不活跃/久坐的 ARD 患者相比，活跃/非久坐的患者 GMT（43.0%[95%CI：11.0-84.0%]）和 FI-GMT（48.0%[95%CI：14.0-92.0%]）更高。观察到剂量反应，每周进行≥350 分钟身体活动的患者组获益更大（比值比：1.6[95%CI：1.1-2.4]；41%[95%CI：10-80%]；35%[95%CI：4.3-74%]，分别为 SC、GMT 和 FI-GMT），而活动最少的组（每周≤30 分钟）获益较少。与不活跃的非 ARD 患者相比，活跃的患者 SC（比值比：9.9[95%CI：1.1-89.0]）和 GMT（26%[95%CI：2.2-56.0%]）更高。
积极的生活方式可能会增强 SARS-CoV-2 疫苗的免疫原性，这对于免疫功能低下的患者具有特殊的临床意义。
Clinicaltrials.gov #NCT04754698。
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