UMR7200 CNRS-Université de Strasbourg, Institut du Médicament de Strasbourg, Faculté de Pharmacie, 67400 Illkirch-Graffenstaden, France.
UMR7199 CNRS-Université de Strasbourg, Faculté de Pharmacie, 67400 Illkirch-Graffenstaden, France.
Bioinformatics. 2022 Mar 4;38(6):1743-1744. doi: 10.1093/bioinformatics/btab860.
The 3D structure of transmembrane helices plays a key role in the function of membrane proteins. While visual inspection can usually discern the distinctive features of a helix bundle, simply translating them into a 2D diagram can be difficult. ATOLL (Aligned Transmembrane dOmains Layout fLattening) projects the helix bundle onto the lipid bilayer plane, thereby facilitating the comparison of different structures of the same membrane protein or structures of different membrane proteins.
ATOLL is a program written in Python3. The source code is freely available on the web at https://github.com/LIT-CCM-lab/ATOLL. ATOLL is implemented into a web server (https://atoll.drugdesign.unistra.fr/).
Supplementary data are available at Bioinformatics online.
跨膜螺旋的 3D 结构对膜蛋白的功能起着关键作用。虽然直观检查通常可以辨别出螺旋束的特征，但将其简单地转换为 2D 图可能很困难。ATOLL（对齐跨膜域布局扁平化）将螺旋束投射到脂质双层平面上，从而便于比较同一膜蛋白的不同结构或不同膜蛋白的结构。
ATOLL 是用 Python3 编写的程序。源代码可在网上免费获得，网址为 https://github.com/LIT-CCM-lab/ATOLL。ATOLL 已实现为一个网络服务器（https://atoll.drugdesign.unistra.fr/）。
补充数据可在“Bioinformatics”在线获取。
