Lu Han-Qiang, Wang Run-Kun, Wang Hui-Rong, Zhou Guang-Quan, Zhang Yan-Shu
Department of Otorhinolaryngology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
The Fourth Affiliated Hospital of Nantong University, YanCheng 224006, China.
J Oncol. 2021 Dec 17;2021:6060762. doi: 10.1155/2021/6060762. eCollection 2021.
One of the most frequent malignancies in the head and neck is nasopharyngeal carcinoma (NPC). MicroRNAs, a kind of tiny noncoding RNA molecule, have been used as negative regulators in different types of cancer therapy in recent decades by downregulating their targets. Recent research suggests that microRNAs play an important role in cancer's epithelial-to-mesenchymal transition (EMT), supporting or inhibiting EMT development. The epithelial-to-mesenchymal transition (EMT) is linked to a variety of cancer-related activities, including growth, metastasis, and invasion. Previous research has linked EMT to cancer stem-like characteristics as well as treatment resistance. Moreover, since microRNAs (miRNAs) are important regulators of the EMT phenotype, certain miRNAs have an effect on cancer stemness and treatment resistance. As a result, both fundamental research and clinical therapy benefit from knowing the connection between EMT-associated miRNAs and cancer stemness/drug resistance. As a result, we looked at the different functions that EMT-associated miRNAs (miR-137) play in the stem-like characteristics of malignant cells in this article. Then we looked at how EMT-associated miRNAs interact with nasopharyngeal cancer's drug-resistant complex signaling pathways. Using qRT-PCR, we evaluated the performance of several micro RNAs with the proposed miR-137 for inhibiting invasion, metastasis, and the EMT process. In conclusion, our findings showed that miR-137 acted as a tumor suppressor gene in controlling NPC EMT and metastasis and that it may be a new therapeutic strategy and prognosis marker for the disease.
鼻咽癌（NPC）是头颈部最常见的恶性肿瘤之一。微小RNA是一种微小的非编码RNA分子，近几十年来，它通过下调其靶标，在不同类型的癌症治疗中被用作负调控因子。最近的研究表明，微小RNA在癌症的上皮-间质转化（EMT）中起重要作用，支持或抑制EMT的发展。上皮-间质转化（EMT）与多种癌症相关活动有关，包括生长、转移和侵袭。先前的研究已将EMT与癌症干细胞样特征以及治疗抗性联系起来。此外，由于微小RNA（miRNA）是EMT表型的重要调节因子，某些miRNA对癌症干性和治疗抗性有影响。因此，了解EMT相关miRNA与癌症干性/耐药性之间的联系，对基础研究和临床治疗都有益处。因此，在本文中，我们研究了EMT相关miRNA（miR-137）在恶性细胞的干细胞样特征中发挥的不同作用。然后我们研究了EMT相关miRNA如何与鼻咽癌的耐药复合信号通路相互作用。我们使用qRT-PCR评估了几种与提议的miR-137一起用于抑制侵袭、转移和EMT过程的微小RNA的性能。总之，我们的研究结果表明，miR-137在控制鼻咽癌EMT和转移中起肿瘤抑制基因的作用，它可能是该疾病的一种新的治疗策略和预后标志物。
