一种基于新型 microRNA 的标志物可预测鼻咽癌患者的预后。
A novel microRNA-based signature predicts prognosis among nasopharyngeal cancer patients.
机构信息
Department of Otolaryngology-Head and Neck Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
Department of Otorhinolaryngology-Head and Neck Surgery, Jiangsu Taizhou People's Hospital, Taizhou 225300, China; *Tianyu Wang, Jian Wu and Yun Wu are contributed equally to this paper.
出版信息
Exp Biol Med (Maywood). 2021 Jan;246(1):72-83. doi: 10.1177/1535370220958680. Epub 2020 Sep 17.
Abstract
Nasopharyngeal cancer is one of the most common malignant tumors in the head and neck. Identification of promising miRNA biomarkers might benefit a lot to the detection of nasopharyngeal carcinoma. A three-miRNA signature (has-miR-142-3p, has-miR-29c, and has-miR-30e) was obviously associated with the overall survival of nasopharyngeal carcinoma patients. The model has better clinical independence and has better clinical prediction effect when combined with clinical characteristics. Our results revealed that a three-miRNA signature was a potential novel prognostic biomarker for nasopharyngeal carcinoma.
摘要
鼻咽癌是头颈部最常见的恶性肿瘤之一。鉴定有前途的 miRNA 生物标志物可能会极大地受益于鼻咽癌的检测。一个三 miRNA 特征（has-miR-142-3p、has-miR-29c 和 has-miR-30e）与鼻咽癌患者的总生存率明显相关。该模型与临床特征相结合时具有更好的临床独立性和更好的临床预测效果。我们的研究结果表明，三 miRNA 特征是一种潜在的鼻咽癌新型预后生物标志物。
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