Smith S M, Levy N S, Hayes C E
J Nutr. 1987 May;117(5):857-65. doi: 10.1093/jn/117.5.857.
Vitamin A deficiency was produced in mice and was used to investigate the role of vitamin A in immune function. Cellular immunity, as measured by delayed-type hypersensitivity, diminished in early deficiency before weight and appetite changes occurred and declined further as the deficiency progressed. Humoral immunity, as measured by serum immunoglobulin M (IgM) responses to a protein antigen (hemocyanin), also declined. The kinetics of antibody production were unaffected by the deficiency. The T-cell number remained unchanged, but B-cell and macrophage numbers were increased in vitamin A--deficient mice. Surface expression of membrane glycoproteins (Thy-1, Lyt-1, Lyt-2, L3T4, IgM, Mac-1) was unchanged by the deficiency, as were lymphocyte numbers and distribution. The results suggest that vitamin A deficiency is associated with a functional immune system defect.
在小鼠中制造维生素A缺乏症，并用其研究维生素A在免疫功能中的作用。通过迟发型超敏反应测定的细胞免疫，在体重和食欲变化出现之前的早期缺乏阶段就有所减弱，并随着缺乏情况的发展而进一步下降。通过血清免疫球蛋白M（IgM）对蛋白质抗原（血蓝蛋白）的反应测定的体液免疫也下降了。抗体产生的动力学不受缺乏症的影响。T细胞数量保持不变，但维生素A缺乏的小鼠中B细胞和巨噬细胞数量增加。膜糖蛋白（Thy-1、Lyt-1、Lyt-2、L3T4、IgM、Mac-1）的表面表达以及淋巴细胞数量和分布不受缺乏症的影响。结果表明，维生素A缺乏与功能性免疫系统缺陷有关。
