Yamagata H, Akizuki M, Tojo T, Homma M
Scand J Rheumatol Suppl. 1986;61:98-101.
The frequency of anti-Ro/SSA and anti-La/SSB antibodies in patients from Japan with Sjögren's syndrome, systemic lupus erythematosus (SLE), progressive systemic sclerosis (PSS), polymyositis-dermatomyositis (PM-DM), rheumatoid arthritis (RA) and blood donors is reported. Anti-La/SSB ab was especially detected in patients with severe glandular and extraglandular manifestation and could be found in sera years prior to the confirmation of Sjögren's syndrome. The purified Ro/SSA antigen consisted of 60 k peptide and 16 k RNA while the La/SSB antigen consisted of 41 k and 29 k peptides. Some molecular association seems to exist between the peptides and corresponding IgG anti-Ro/SSA and anti-La/SSB antibodies.
报告了来自日本的干燥综合征、系统性红斑狼疮（SLE）、进行性系统性硬化症（PSS）、多发性肌炎-皮肌炎（PM-DM）、类风湿关节炎（RA）患者及献血者中抗Ro/SSA和抗La/SSB抗体的频率。抗La/SSB抗体尤其在有严重腺体和腺外表现的患者中检测到，并且在确诊干燥综合征数年之前的血清中就能发现。纯化的Ro/SSA抗原由60k肽和16k RNA组成，而La/SSB抗原由41k和29k肽组成。这些肽与相应的抗Ro/SSA和抗La/SSB IgG抗体之间似乎存在某种分子关联。
