Fossaluzza V, De Vita S
4th General Medicine Division, S. Maria della Misericordia Civilian Hospital, Udine, Italy.
Clin Rheumatol. 1992 Sep;11(3):385-7. doi: 10.1007/BF02207198.
Fifty female patients with primary Sjögren's syndrome diagnosed according to the Copenhagen criteria were evaluated for both glandular and extraglandular involvement. They were divided into two groups based on the presence or absence of antinuclear and anti-ENA antibodies (ANA/anti-ENA). ANA/anti-ENA negative patients presented with milder and later glandular and extraglandular disease and required less frequent corticosteroid treatment. No significant differences were noted in extraglandular manifestations with the exception of leukopenia which was noted only in ANA/anti-ENA positive cases.
根据哥本哈根标准诊断的50例原发性干燥综合征女性患者接受了腺体和腺外受累情况的评估。根据抗核抗体和抗可提取性核抗原抗体（ANA/抗-ENA）的有无，将她们分为两组。ANA/抗-ENA阴性的患者腺体和腺外疾病较轻且出现较晚，所需的皮质类固醇治疗频率较低。除了白细胞减少症仅在ANA/抗-ENA阳性病例中出现外，腺外表现未发现显著差异。
