Reed J C, Tsujimoto Y, Alpers J D, Croce C M, Nowell P C
Science. 1987 Jun 5;236(4806):1295-9. doi: 10.1126/science.3495884.
The bcl-2 and c-myc proto-oncogenes are brought into juxtaposition with the immunoglobulin heavy chain locus in particular B-cell lymphomas, resulting in high levels of constitutive accumulation of their messenger RNAs. Precisely how the products of the bcl-2 and c-myc genes contribute to tumorigenesis is unknown, but observations that c-myc expression is rapidly induced in nonneoplastic lymphocytes upon stimulation of proliferation raise the possibility that this proto-oncogene is involved in the control of normal cellular growth. In addition to c-myc, the bcl-2 proto-oncogene also was expressed in normal human B and T lymphocytes after stimulation with appropriate mitogens. Comparison of the regulation of the expression of these proto-oncogenes demonstrated marked differences and provided evidence that, in contrast to c-myc, levels of bcl-2 messenger RNA are regulated primarily through transcriptional mechanisms.
在某些特定的B细胞淋巴瘤中，bcl-2和c-myc原癌基因与免疫球蛋白重链基因座并列，导致其信使RNA高水平的组成性积累。bcl-2和c-myc基因的产物究竟如何促进肿瘤发生尚不清楚，但有观察表明，在非肿瘤性淋巴细胞受到增殖刺激后，c-myc表达会迅速被诱导，这增加了这种原癌基因参与正常细胞生长调控的可能性。除了c-myc，bcl-2原癌基因在用适当的促细胞分裂剂刺激后的正常人B淋巴细胞和T淋巴细胞中也有表达。对这些原癌基因表达调控的比较显示出显著差异，并提供了证据，与c-myc相反，bcl-2信使RNA的水平主要通过转录机制进行调控。
