Paudel Keshav Raj, Jha Saurav Kumar, Allam Venkata Sita Rama Raju, Prasher Parteek, Gupta Piyush Kumar, Bhattacharjee Rahul, Jha Niraj Kumar, Vishwas Sukriti, Singh Sachin K, Shrestha Jesus, Imran Mohammad, Panth Nisha, Chellappan Dinesh Kumar, Ebrahimi Warkiani Majid, Hansbro Philip M, Dua Kamal
Centre for Inflammation, Centenary Institute, Sydney, NSW 2050, Australia.
School of Life Sciences, University of Technology Sydney, Sydney, NSW 2007, Australia.
Pharmaceutics. 2021 Nov 25;13(12):2008. doi: 10.3390/pharmaceutics13122008.
Respiratory diseases contribute to a significant percentage of mortality and morbidity worldwide. The circadian rhythm is a natural biological process where our bodily functions align with the 24 h oscillation (sleep-wake cycle) process and are controlled by the circadian clock protein/gene. Disruption of the circadian rhythm could alter normal lung function. Chronotherapy is a type of therapy provided at specific time intervals based on an individual's circadian rhythm. This would allow the drug to show optimum action, and thereby modulate its pharmacokinetics to lessen unwanted or unintended effects. In this review, we deliberated on the recent advances employed in chrono-targeted therapeutics for chronic respiratory diseases.
呼吸系统疾病在全球死亡率和发病率中占相当大的比例。昼夜节律是一种自然的生物过程，我们的身体功能与24小时振荡（睡眠-觉醒周期）过程同步，并由昼夜节律时钟蛋白/基因控制。昼夜节律的破坏可能会改变正常的肺功能。时间治疗是一种根据个体昼夜节律在特定时间间隔进行的治疗方法。这将使药物发挥最佳作用，从而调节其药代动力学，以减少不良或意外影响。在这篇综述中，我们探讨了针对慢性呼吸系统疾病的时辰靶向治疗的最新进展。
