Center for Fundamental Education, Teikyo University of Science, Tokyo 120-0045, Japan.
Research & Development Division, Mitsui Sugar Co., Ltd., Tokyo 103-8423, Japan.
Nutrients. 2021 Dec 15;13(12):4493. doi: 10.3390/nu13124493.
Increased arterial stiffness during acute hyperglycemia is a risk factor for cardiovascular disease, but the type of carbohydrate that inhibits it is unknown. The purpose of this study was to determine the efficacy of low-glycemic-index isomaltulose on arterial stiffness during hyperglycemia in middle-aged and older adults. Ten healthy middle-aged and older adult subjects orally ingested a solution containing 25 g of isomaltulose (ISI trial) and sucrose (SSI trial) in a crossover study. In the SSI trial, the brachial-ankle (ba) pulse wave velocity (PWV) increased 30, 60, and 90 min after ingestion compared with that before ingestion ( < 0.01); however, in the ISI trial, the baPWV did not change after ingestion compared with that before ingestion. Blood glucose levels 30 min after intake were lower in the ISI trial than in the SSI trial ( < 0.01). The baPWV and systolic blood pressure were positively correlated 90 min after isomaltulose and sucrose ingestion ( = 0.640, < 0.05). These results indicate that isomaltulose intake inhibits an acute increase in arterial stiffness. The results of the present study may have significant clinical implications on the implementation of dietary programs for middle-aged and elderly patients.
急性高血糖期间动脉僵硬增加是心血管疾病的一个危险因素，但抑制它的碳水化合物类型尚不清楚。本研究的目的是确定低血糖指数异麦芽酮糖在中年和老年人高血糖期间对动脉僵硬的疗效。10 名健康的中年和老年人在一项交叉研究中口服含有 25 克异麦芽酮糖（ISI 试验）和蔗糖（SSI 试验）的溶液。在 SSI 试验中，与摄入前相比，摄入后 30、60 和 90 分钟时肱踝（ba）脉搏波速度（PWV）增加（<0.01）；然而，在 ISI 试验中，摄入后 baPWV 与摄入前相比没有变化。ISI 试验中摄入后 30 分钟的血糖水平低于 SSI 试验（<0.01）。异麦芽酮糖和蔗糖摄入后 90 分钟时 baPWV 和收缩压呈正相关（=0.640，<0.05）。这些结果表明，异麦芽酮糖的摄入抑制了动脉僵硬的急性增加。本研究的结果可能对中年和老年患者实施饮食计划具有重要的临床意义。
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