Li Saiqun, Jia Xiuhua, Yu Fei, Wang Qian, Zhang Tingting, Yuan Jin
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510623, China.
Department of Ophthalmology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China.
Vaccines (Basel). 2021 Nov 25;9(12):1394. doi: 10.3390/vaccines9121394.
The global Coronavirus Disease 2019 (COVID-19) pandemic has accelerated vaccine development at an unprecedented rate. A large population of people have received COVID-19 vaccines, while the vaccine safety data are limited. Here, we reported two cases of herpetic keratitis that occurred soon after receiving the inactivated COVID-19 vaccines. Case 1 was a 60-year-old woman who underwent penetrating keratoplasty (PKP) one year ago for corneal scarring caused by herpes simplex keratitis (HSK), and case 2 was a 51-year-old man with an unremarkable medical history. Both patients developed herpetic keratitis (HSK and varicella-zoster virus corneal endotheliitis, respectively) soon after receiving the inactivated COVID-19 vaccines (Sinovac). Herpetic keratitis was treated successfully with topical or plus oral antiviral ganciclovir. The short latency time in these two cases suggested that an inactivated COVID-19 vaccine may have a risk of triggering ocular herpes virus reactivation. Both clinicians and patients should be aware of this phenomenon. However, a causal relationship awaits confirmation.
全球2019冠状病毒病（COVID-19）大流行以前所未有的速度加速了疫苗的研发。大量人群已经接种了COVID-19疫苗，而疫苗安全性数据有限。在此，我们报告了两例接种新型冠状病毒灭活疫苗后不久发生疱疹性角膜炎的病例。病例1是一名60岁女性，一年前因单纯疱疹病毒性角膜炎（HSK）导致角膜瘢痕接受了穿透性角膜移植术（PKP）；病例2是一名51岁男性，既往病史无特殊。两名患者在接种新型冠状病毒灭活疫苗（科兴中维）后不久均发生了疱疹性角膜炎（分别为HSK和水痘-带状疱疹病毒性角膜内皮炎）。局部或联合口服抗病毒药物更昔洛韦成功治疗了疱疹性角膜炎。这两例病例潜伏期短，提示新型冠状病毒灭活疫苗可能存在引发眼部疱疹病毒再激活的风险。临床医生和患者均应意识到这一现象。然而，因果关系尚待证实。
