低纳米金刚石浓度和聚合技术对义齿基托树脂物理性能及抗真菌活性的影响
Effect of Low Nanodiamond Concentrations and Polymerization Techniques on Physical Properties and Antifungal Activities of Denture Base Resin.
作者信息
Fouda Shaimaa M, Gad Mohammed M, Ellakany Passent, Al Ghamdi Maram A, Khan Soban Q, Akhtar Sultan, Al Eraky Doaa M, Al-Harbi Fahad A
机构信息
Department of Substitutive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.
Department of Dental Education, College of Dentistry, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.
出版信息
Polymers (Basel). 2021 Dec 10;13(24):4331. doi: 10.3390/polym13244331.
BACKGROUND
Denture base resin has some drawbacks. This study investigated the impact of nanodiamonds (ND) and autoclave polymerization on the surface characteristics, translucency, and adherence in polymethyl methacrylate (PMMA) denture base resin after thermocycling.
METHODS
Heat-polymerized PMMA discs (15 × 2 mm) with a total sample size = 160 were studied. Specimens were categorized into two main groups ( = 80): conventional water-bath-polymerized PMMA (CP/PMMA) and autoclave-polymerized PMMA (AP/PMMA). Each group was subdivided according to the ND concentration into four groups ( = 20): unmodified PMMA as a control, and 0.1%, 0.25%, and 0.5% ND-PMMA. Scanning electron microscopy (SEM) was used to inspect the morphology of the ND and the ND-PMMA mixtures before heat polymerization. The specimens were exposed to thermal cycling (5000 cycles at 5 and 55 °C), then surface roughness was measured with a non-contact optical interferometric profilometer, contact angle with an automated goniometer, and translucency using a spectrophotometer. Colony-forming units (CFU) were used to determine the adherence of cells to the specimens. ANOVA and Tukey post hoc tests for pairwise comparison were utilized for the statistical analysis (α = 0.05).
RESULTS
Surface roughness was significantly reduced with ND addition to CP/PMMA ( ˂ 0.001), while the reduction was not statistically significant in AP/PMMA ( = 0.831). The addition of ND significantly reduced the contact angle, translucency, and count of CP/PMMA and AP/PMMA ( ˂ 0.001). The incorporation of ND in conjunction with autoclave polymerization of PMMA showed significant reduction in all tested properties (surface roughness, contact angle and adherence) except translucency ( = 0.726).
CONCLUSIONS
ND addition to PMMA and autoclave polymerization improved the surface properties with respect to antifungal activities, while the translucency was adversely affected.
背景
义齿基托树脂存在一些缺点。本研究调查了纳米金刚石（ND）和高压釜聚合对热循环后聚甲基丙烯酸甲酯（PMMA）义齿基托树脂的表面特性、半透明度和附着力的影响。
方法
研究了总样本量为160的热聚合PMMA圆盘（15×2 mm）。标本分为两个主要组（每组80个）：传统水浴聚合PMMA（CP/PMMA）和高压釜聚合PMMA（AP/PMMA）。每组根据ND浓度再细分为四组（每组20个）：未改性PMMA作为对照，以及0.1%、0.25%和0.5% ND-PMMA。扫描电子显微镜（SEM）用于检查热聚合前ND和ND-PMMA混合物的形态。标本进行热循环（在5和55°C下循环5000次），然后用非接触式光学干涉轮廓仪测量表面粗糙度，用自动测角仪测量接触角，用分光光度计测量半透明度。用菌落形成单位（CFU）来确定细胞对标本的附着力。采用方差分析和Tukey事后检验进行两两比较，用于统计分析（α = 0.05）。
结果
在CP/PMMA中添加ND后表面粗糙度显著降低（P ˂ 0.001），而在AP/PMMA中降低不具有统计学意义（P = 0.831）。添加ND显著降低了CP/PMMA和AP/PMMA的接触角、半透明度和CFU计数（P ˂ 0.001）。ND与PMMA的高压釜聚合相结合，除半透明度外（P = 0.726），所有测试性能（表面粗糙度、接触角和附着力）均显著降低。
结论
在PMMA中添加ND和高压釜聚合改善了抗真菌活性方面的表面性能，但对半透明度有不利影响。
Zotero 插件