连接酞菁锌与丙烯酰氯 - 乙烯基吡咯烷酮共聚物的光物理性质
Photophysical Properties of Linked Zinc Phthalocyanine to Acryloyl Chloride:-vinylpyrrolidone Copolymer.
作者信息
Potlog Tamara, Lungu Ion, Tiuleanu Pavel, Robu Stefan
机构信息
Physics Department and Engineering, Moldova State University, MD 2009 Chisinau, Moldova.
The Faculty of Chemistry and Chemical Technology, Moldova State University, MD 2009 Chisinau, Moldova.
出版信息
Polymers (Basel). 2021 Dec 17;13(24):4428. doi: 10.3390/polym13244428.
This paper focuses on the linking of zinc phthalocyanine (ZnPc) to -vinylpyrrolidone (-VP): acryloyl chloride (ClAC) copolymer. The synthesis of binary -VP:ClAC copolymer was performed by the radical polymerization method and then grafted to ZnPc by the Friedel Crafts acylation reaction. We have developed a water-soluble ZnPc:ClAC:-VP photosensitizer with a narrow absorption band at 970 nm, fluorescence at λ = 825 nm and the decay fluorescence profile with 3-decay relatively longer times of 1.2 µs, 4.6 µs, and 37 µs. The concentration-dependent dark cytotoxicity investigated in normal fibroblasts (NHDF), malignant melanoma (MeWo), adenocarcinoma (HeLa), and hepatocellular carcinoma (HepG2) cell lines incubated to increased concentrations of ZnPc:ClAC:-VP (up to 40 μM) for 24 h in the dark show low cytotoxicity. Maximum cell viability in HeLa and HepG2 tumor cell lines was observed.
本文重点关注酞菁锌（ZnPc）与N-乙烯基吡咯烷酮（N-VP）：丙烯酰氯（ClAC）共聚物的连接。二元N-VP：ClAC共聚物通过自由基聚合法合成，然后通过傅克酰基化反应接枝到ZnPc上。我们开发了一种水溶性ZnPc：ClAC：N-VP光敏剂，其在970 nm处具有窄吸收带，在λ = 825 nm处有荧光，并且衰减荧光曲线具有相对较长的三个衰减时间，分别为1.2 μs、4.6 μs和37 μs。在正常成纤维细胞（NHDF）、恶性黑色素瘤（MeWo）、腺癌（HeLa）和肝癌（HepG2）细胞系中，对浓度增加的ZnPc：ClAC：N-VP（高达40 μM）进行24小时黑暗孵育，研究其浓度依赖性暗细胞毒性，结果显示细胞毒性较低。在HeLa和HepG2肿瘤细胞系中观察到了最大细胞活力。
Zotero 插件