Novel phthalocyanine-based polymeric micelles with high near-infrared photothermal conversion efficiency under 808 nm laser irradiation for in vivo cancer therapy.

Photothermal therapy (PTT) has emerged as one of the promising methodologies for the treatment of cancer, and ideal photothermal agents need to be biodegradable and have strong optical absorbance in the near-infrared (NIR) optical window. Here, we report a new phthalocyanine molecule, 4OCSPC, which expands the absorbance edge to 850 nm. Under 808 nm NIR laser irradiation, 4OCSPC polymeric micelles showed robust photostability and a high photothermal conversion of 47.0%. Also, the 4OCSPC polymeric micelles exhibit a high in vivo PTT efficacy against 4T1 tumors in mice.