Laboratory for Advanced Analysis of Neuroimages, Faculty of Physical Chemistry, University of Belgrade, 12-16 Studentski Trg Street, Belgrade, 11000, Serbia.
Laboratory for Neurocognition and Applied Cognition, Department of Psychology, Faculty of Philosophy, University of Belgrade, Belgrade, Serbia.
J Headache Pain. 2021 Dec 27;22(1):157. doi: 10.1186/s10194-021-01375-8.
This study aimed to examine the N400 effect and event-related potentials (ERPs) elicited from congruent and incongruent stimuli in patients who have migraines with aura (MwA).
A total of 33 MwA patients and 20 healthy controls (HCs) were studied. They were balanced in age (35.12 ± 8.94 vs 34.70 ± 9.59 years, p = 0.872) and sex (69.7 vs 75.0% females, p = 0.761). ERPs were measured in response to both stimuli, where pictures were preceded with an object name that either matched or mismatched with the object. Averaged amplitudes, peaks, peak latencies, difference waves and topography were compared between MwA and HCs.
MwA patients had significantly lower averaged amplitudes at the Fz and F4 sites during incongruent stimuli, as well as reduced peaks at the C3 and Pz sites. Topography showed a more widespread N400 effect over scalp relative to HCs. The difference ERP waveforms did not differ in the N400 effect between groups, but the P600 effect was significantly stronger in the HCs group relative to the MwA group at the Pz (6.52 ± 2.57 vs. 3.50 ± 3.15, p = 0.001) and P4 (5.86 ± 2.79 vs. 3.95 ± 3.64, p = 0.040) sites.
Picture-word matching tasks could serve as a potential new method for the investigation of semantic processing in MwA patients.
本研究旨在检查偏头痛伴先兆（MwA）患者对一致和不一致刺激产生的 N400 效应和事件相关电位（ERP）。
共纳入 33 例 MwA 患者和 20 例健康对照（HC）。两组在年龄（35.12±8.94 岁 vs. 34.70±9.59 岁，p=0.872）和性别（69.7% vs. 75.0%女性，p=0.761）方面相匹配。分别对两种刺激进行 ERP 测量，其中图片之前会出现与图片匹配或不匹配的物体名称。比较 MwA 组和 HCs 组之间的平均振幅、峰值、峰潜伏期、差异波和地形图。
与 HCs 相比，MwA 患者在不一致刺激时 Fz 和 F4 位置的平均振幅显著降低，C3 和 Pz 位置的峰值降低。相对于 HCs，地形图显示 N400 效应在头皮上的分布更广泛。两组之间的 N400 效应差异波无差异，但 Pz 位置的 P600 效应在 HCs 组显著强于 MwA 组（6.52±2.57 比 3.50±3.15，p=0.001）和 P4 位置（5.86±2.79 比 3.95±3.64，p=0.040）。
图片-文字匹配任务可能成为研究 MwA 患者语义处理的一种新方法。
