Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Health Science Center, No.1066 Xueyuan Avenue, Nanshan District, Shenzhen, Guangdong 518060, People's Republic of China.
Department of Health Management, Beijing Xiaotangshan Hospital, Xiaotangshan Town, Changping, Beijing 102200, People's Republic of China.
Nutr Metab Cardiovasc Dis. 2022 Mar;32(3):550-559. doi: 10.1016/j.numecd.2021.10.020. Epub 2021 Nov 10.
The purpose of this study is to explore the relationship between Chinese visceral adipose index (CVAI) and the risk of coronary heart disease (CHD) in Chinese through a large cohort study.
This study included 42,165 adults who were without CHD at baseline and who completed at least one annual follow-up between 2009 and 2016. We used the Cox proportional hazards model to estimate Hazard Ratios (HRs) and 95% Confidence Intervals (CIs) for the association between CVAI and risk of CHD. During the median follow-up of 3.36 years (154,808 person years), 520 participants developed CHD, including 374 males and 146 females. Compared with the first quartile of CVAI, the risk of CHD was significantly increased in the fourth quartile of CVAI in multivariate model (HR [95% CI]: 9.92 [5.45, 18.04], P < 0.001). Sensitivity analysis by excluding incident CHD developed in the first two years of follow-up reinforced our results. Gender stratification analyses showed that the relationship between CVAI and CHD risk was higher in males than that in females. The restricted cubic spline showed a non-linear dose-response relationship between CVAI and CHD risk. In addition, CVAI was associated with CHD risk in the subgroups of participants without T2DM, without hypertension, and without fatty liver.
CVAI was significantly associated with the risk of CHD. Individuals should keep CVAI at normal level to prevent CHD.
本研究旨在通过一项大型队列研究，探讨中国人内脏脂肪指数（CVAI）与冠心病（CHD）风险之间的关系。
本研究纳入了 42165 名基线时无 CHD 且在 2009 年至 2016 年期间至少完成一次年度随访的成年人。我们使用 Cox 比例风险模型来估计 CVAI 与 CHD 风险之间的关联的风险比（HR）和 95%置信区间（CI）。在中位数为 3.36 年（154808 人年）的随访期间，520 名参与者发生了 CHD，包括 374 名男性和 146 名女性。与 CVAI 的第一四分位相比，在多变量模型中，CVAI 的第四四分位与 CHD 的风险显著增加（HR [95%CI]：9.92 [5.45，18.04]，P<0.001）。通过排除随访前两年发生的新发 CHD 的敏感性分析进一步证实了我们的结果。性别分层分析表明，CVAI 与 CHD 风险之间的关系在男性中高于女性。受限立方样条显示 CVAI 与 CHD 风险之间存在非线性剂量反应关系。此外，在无 T2DM、无高血压和无脂肪肝的参与者亚组中，CVAI 与 CHD 风险相关。
CVAI 与 CHD 风险显著相关。个体应将 CVAI 保持在正常水平，以预防 CHD。
