Jiangxi Key Laboratory of Natural Products and Functional Food, Jiangxi Agricultural University, Nanchang 330045, China.
Department of Agricultural Food and Nutritional Science, Faculty of Agricultural Life and Environmental Sciences, University of Alberta, Edmonton, Alberta T6G 2R3, Canada.
J Agric Food Chem. 2022 Jan 12;70(1):5-20. doi: 10.1021/acs.jafc.1c04742. Epub 2021 Dec 28.
Oxidative stress and chronic inflammation are the common pathological bases of chronic diseases such as atherosclerosis, cancer, and cardiovascular diseases, but most of the treatment drugs for chronic diseases have side effects. There is an increasing interest to identify food-derived bioactive compounds that can mitigate the pathological pathways associated with oxidative stress and chronic inflammation. Egg white contain a variety of biologically active proteins, many of which have antioxidant and anti-inflammatory activities and usually show better activity after enzymatic hydrolysis. This review covers the antioxidative stress and anti-inflammatory activities of egg white proteins and their derived peptides and clarifies their mechanism of action and . In addition, the link between oxidative stress and inflammation as well as their markers are reviewed. It suggests the potential application of egg white proteins and their derived peptides and puts forward further research prospects.
氧化应激和慢性炎症是动脉粥样硬化、癌症和心血管疾病等慢性病的共同病理基础，但大多数慢性病的治疗药物都有副作用。人们越来越感兴趣的是识别食物来源的生物活性化合物，这些化合物可以减轻与氧化应激和慢性炎症相关的病理途径。蛋清含有多种具有生物活性的蛋白质，其中许多具有抗氧化和抗炎活性，通常在酶解后表现出更好的活性。本文综述了蛋清蛋白及其衍生肽的抗氧化应激和抗炎活性，并阐明了其作用机制。此外，还综述了氧化应激和炎症之间的联系及其标志物。它表明了蛋清蛋白及其衍生肽的潜在应用，并提出了进一步的研究前景。
