在可持续溶剂二甲基异山梨醇中，镍催化芳基溴化物与醋酸乙烯酯的还原交叉偶联反应。
Nickel-Catalyzed Reductive Cross-Coupling of Aryl Bromides with Vinyl Acetate in Dimethyl Isosorbide as a Sustainable Solvent.
作者信息
Su Mincong, Huang Xia, Lei Chuanhu, Jin Jian
机构信息
Center for Supramolecular Chemistry and Catalysis and Department of Chemistry, College of Sciences, Shanghai University, 99 Shangda Road, Shanghai 200444, China.
CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
出版信息
Org Lett. 2022 Jan 14;24(1):354-358. doi: 10.1021/acs.orglett.1c04018. Epub 2021 Dec 28.
A nickel-catalyzed reductive cross-coupling has been achieved using (hetero)aryl bromides and vinyl acetate as the coupling partners. This mild, applicable method provides a reliable access to a variety of vinyl arenes, heteroarenes, and benzoheterocycles, which should expand the chemical space of precursors to fine chemicals and polymers. Importantly, a sustainable solvent, dimethyl isosorbide, is used, making this protocol more attractive from the point of view of green chemistry.
使用（杂）芳基溴化物和醋酸乙烯酯作为偶联伙伴，实现了镍催化的还原交叉偶联反应。这种温和且适用的方法为各种乙烯基芳烃、杂芳烃和苯并杂环化合物提供了可靠的合成途径，这将拓展精细化学品和聚合物前体的化学空间。重要的是，该反应使用了可持续的溶剂二甲基异山梨醇，从绿色化学的角度来看，使得该方法更具吸引力。
Zotero 插件