Technical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, P. R. China.
Institute of Material Physics & Chemistry, College of Science, Nanjing Forestry University, Nanjing 210037, China.
J Org Chem. 2022 Jun 17;87(12):8048-8058. doi: 10.1021/acs.joc.2c00707. Epub 2022 Jun 6.
A visible-light-promoted nickel/photoredox-catalyzed reductive cross-coupling reaction between vinyl bromides and benzyl chlorides is reported. A diverse array of enantioenriched allylic centers containing products could be achieved in good yields (up to 90%) and high enantioselectivities (up to 95% ee). The mechanistic studies show that this reductive cross-coupling involves a radical pathway.
报道了一种可见光促进的镍/光氧化还原催化的溴代乙烯和氯代苄基之间的还原交叉偶联反应。通过该方法可以以良好的收率（高达 90%）和高对映选择性（高达 95%ee）获得多种手性烯丙基中心产物。机理研究表明，这种还原交叉偶联反应涉及自由基途径。
