新生大鼠经口灌胃钚后肠道α射线照射所致急性损伤

Acute lesions induced by alpha-irradiation of intestine after plutonium gavage of neonatal rats.

作者信息

Fritsch P, Beauvallet M, Moutairou K, Metivier H, Masse R

出版信息

Int J Radiat Biol Relat Stud Phys Chem Med. 1987 Jul;52(1):1-6. doi: 10.1080/09553008714551421.

Abstract

After gavage of two-day-old rats with 238Pu(IV)-citrate at 17.4 MBq/kg (122 kBq per animal), 45 per cent of the animals died during the second week following ingestion. Histological analysis showed that death was due to acute intestinal lesions caused by alpha-radiation that resulted in denudation of the ileum. Under these experimental conditions, the total alpha-dose delivered to the ileal wall and its contents was estimated at 150 Gy. No acute lesions were observed after gavage of two-day-old rats with Pu-citrate at 5.3 MBq/kg.

摘要

给两日龄大鼠经口灌胃柠檬酸钚（IV），剂量为17.4 MBq/kg（每只动物122 kBq），45%的动物在摄入后的第二周死亡。组织学分析表明，死亡是由α辐射引起的急性肠道损伤导致回肠剥脱所致。在这些实验条件下，回肠壁及其内容物所接受的总α剂量估计为150 Gy。给两日龄大鼠经口灌胃剂量为5.3 MBq/kg的柠檬酸钚后，未观察到急性损伤。