[评估238钚掺入哺乳动物后的遗传后果]

[Evaluation of genetic consequences of 238Pu incorporation into mammals].

作者信息

Pomerantseva M D, Ramaĭia L K, Shevchenko V A, Vilkina G A, Liaginskaia A M

出版信息

Genetika. 1988 Apr;24(4):671-81.

Abstract

The genetic effects of gonadal burdens of 238Pu after single injection were studied in male mice. The activity of plutonium was 7 to 1850 Bk/g. The average doses of accumulated alpha-particles in testis varied from 2 to 96 Gy.10(-2), the dose rate being 0.004 to 1 Gy.10(-2) per day. The genetic end points are: the dominant lethal mutation rate; the frequency of reciprocal translocations; the recessive lethal mutation rate and frequency of abnormal sperm head morphology. For all tests used, no linear dependence of the effect on the alpha-dose was observed. The RBE value of alpha-irradiation was 10-20 relative to chronic gamma-irradiation.

摘要

对单次注射后雄性小鼠体内钚 - 238性腺负荷的遗传效应进行了研究。钚的活度为7至1850贝克勒尔/克。睾丸中累积的α粒子平均剂量在2至96戈瑞×10⁻²之间，剂量率为每天0.004至1戈瑞×10⁻²。遗传终点包括：显性致死突变率；相互易位频率；隐性致死突变率和异常精子头部形态频率。对于所有使用的测试，均未观察到效应与α剂量之间的线性关系。相对于慢性γ辐射，α辐射的相对生物效应值为10至20。