Kurrimboccus Fadilah, Orchard Ané, Danckwerts Michael Paul, van Vuuren Sandy
Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Planta Med. 2022 Oct;88(13):1256-1262. doi: 10.1055/a-1699-3284. Epub 2021 Dec 28.
Acne is a skin condition arising from excess sebum production and microbial overgrowth within the pilosebaceous unit. Several commercial essential oils have shown promising activity against acne-related pathogens. Due to their volatility and thermal instability, the formulation of essential oils into commercial products remains a pharmaceutical challenge. Thus, this study aimed to develop a viable anti-acne topical treatment as an oil-in-water emulsified lotion to overcome these challenges. (vetiver) displayed noteworthy antimicrobial activity with a mean minimum inhibitory concentration of 0.14 mg/mL against , and . Emulsified lotions containing were developed through the hydrophilic-lipophilic balance approach. At tested hydrophilic-lipophilic balance values of 8, 9, and 10, emulsified lotions displayed maximum stability at hydrophilic-lipophilic balance 9 with a minimum change in mean droplet size and polydispersity index of 20.61 and 33.33%, respectively, over 84 days. The emulsified lotion at optimum hydrophilic-lipophilic balance 9 completely inhibited the growth of and killed , and within 24 h. Additionally, the lotion retained antimicrobial activity against these test micro-organisms over the 84-day stability test period. Thus, the emulsified lotion demonstrated physical stability and antimicrobial efficiency, making it an ideal natural product anti-acne treatment.
痤疮是一种由于皮脂腺单位内皮脂分泌过多和微生物过度生长而引发的皮肤疾病。几种商业精油已显示出对痤疮相关病原体具有可观的活性。由于其挥发性和热不稳定性，将精油制成商业产品仍然是一个制药挑战。因此，本研究旨在开发一种可行的抗痤疮局部治疗方法，制成水包油乳化乳液以克服这些挑战。（香根草）表现出显著的抗菌活性，对[具体微生物1]、[具体微生物2]的平均最低抑菌浓度为0.14mg/mL。通过亲水亲油平衡法开发了含有[香根草提取物]的乳化乳液。在测试的亲水亲油平衡值为8、9和10时，[香根草提取物]乳化乳液在亲水亲油平衡值为9时表现出最大稳定性，在84天内平均液滴尺寸和多分散指数的最小变化分别为20.61%和33.33%。在最佳亲水亲油平衡值为9时的[香根草提取物]乳化乳液在24小时内完全抑制了[具体微生物1]的生长并杀死了[具体微生物2]和[具体微生物3]。此外，在84天的稳定性测试期间，该乳液对这些测试微生物保持抗菌活性。因此，[香根草提取物]乳化乳液表现出物理稳定性和抗菌效率，使其成为理想的天然抗痤疮治疗产品。
