Chen K B, Ji J, Li H, Chen X W, Ding X
Department of Otorhinolaryngology Head and Neck Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, China.
Department of Otorhinolaryngology Head and Neck Surgery, The First People's Hospital of Lanzhou, Lanzhou 730000, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Dec 7;56(12):1300-1306. doi: 10.3760/cma.j.cn115330-20210330-00158.
To evaluate the effect of daily average temperature on the atteck of allergic rhinitis (AR) by analyzing the changes of the outpatient visits of AR in Lanzhou. The meteorological and air pollution data of Lanzhou City and the outpatient visits of AR in Departments of Otorhinolaryngology and head and neck surgery of The First Hospital of Lanzhou University, The Second Hospital of Lanzhou University and Gansu Provincial People's Hospital from 2013 to 2017 were collected to describe the meteorological factors, air pollutants and the outpatient visits of AR. The correlation among the three factors was then analyzed by Spearman rank correlation analysis. Using the distributed lag non-linear model, the relationship between daily average temperature and the number of daily outpatient visits of AR was studied and stratified by gender and age with the long-term trend, seasonal trend and other confounding factors controlled. From 2013 to 2017, the outpatient visits of AR in the above three hospitals reached 20 008 person times. Daily average temperature in Lanzhou showed a non-linear correlation to the outpatient visits of AR, with a certain lag effect. When the daily average temperature was 22 ℃ and the cumulative lag was 21 days (lag 0-21 d), the relative risk (RR) peaked at 4.851 (95: 3.986-5.904). The effect of relatively low temperature (2.3 ℃, ), relatively high temperature (19.8 ℃, ) and high temperature (25.5 ℃, ) on lag 0-21 d were the highest, which were 1.761 (95: 1.375-2.255), 4.299 (95: 3.574-5.171) and 3.656 (95: 3.046-4.389), respectively. According to the stratified analysis, low and relatively low temperature had more significant effect on the outpatient visits of AR among women and people aged 0-14 years. When lag was 0-21 days, the RR value of low temperature for female outpatient visits of AR was 1.433 (95: 1.105-1.860); the RR value of relatively low temperature for female outpatient visits of AR was 1.879 (95: 1.460-2.419); the RR value of low temperature for AR outpatient visits for people aged 0-14 years was 1.511 (95: 0.999-2.287), the RR value of relatively low temperature for AR outpatient visits for people aged 0-14 years was 2.051 (95: 1.383-3.042). Relatively high temperature, on the other hand, had a more significant effect on men and people aged 15-59 years. High temperature had a greater impact on the number of AR outpatients in men and people aged 0-14 years. Temperature may be an important influencing factor of AR onset in Lanzhou. At relatively high temperature (19.8 ℃), the risk of AR outpatient visits is significantly increased, and the cumulative lagged effects are observed. The sensitivity of AR patients to temperature is different in different genders and ages.
通过分析兰州地区变应性鼻炎(AR)门诊量的变化,评估日平均气温对AR发病的影响。收集兰州市2013年至2017年的气象和空气污染数据以及兰州大学第一医院、兰州大学第二医院和甘肃省人民医院耳鼻咽喉头颈外科的AR门诊量,以描述气象因素、空气污染物和AR门诊量情况。然后采用Spearman等级相关分析对这三个因素之间的相关性进行分析。运用分布滞后非线性模型,研究日平均气温与AR日门诊量之间的关系,并在控制长期趋势、季节趋势等混杂因素的情况下,按性别和年龄进行分层分析。2013年至2017年,上述三家医院的AR门诊量达20008人次。兰州市日平均气温与AR门诊量呈非线性相关,且具有一定滞后效应。当日平均气温为22℃且累积滞后21天(滞后0 - 21天)时,相对危险度(RR)峰值为4.851(95%CI:3.986 - 5.904)。在滞后0 - 21天,相对低温(2.3℃)、相对高温(19.8℃)和高温(25.5℃)的影响最高,分别为1.761(95%CI:1.375 - 2.255)、4.299(95%CI:3.574 - 5.171)和3.656(95%CI:3.046 - 4.389)。分层分析显示,低温和相对低温对女性及0 - 14岁人群的AR门诊量影响更显著。当滞后0 - 21天时,低温对女性AR门诊量的RR值为1.433(95%CI:1.105 - 1.860);相对低温对女性AR门诊量的RR值为1.879(95%CI:1.460 - 2.419);低温对0 - 14岁人群AR门诊量的RR值为1.511(95%CI:0.999 - 2.287),相对低温对0 - 14岁人群AR门诊量的RR值为2.051(95%CI:1.383 - 3.042)。另一方面,相对高温对男性及15 - 59岁人群影响更显著。高温对男性及0 - 14岁人群的AR门诊量影响更大。气温可能是兰州地区AR发病的重要影响因素。在相对高温(19.8℃)时,AR门诊量风险显著增加,且存在累积滞后效应。不同性别和年龄的AR患者对温度的敏感性不同。