Wu Rongshan, Guo Qun, Fan Jingpu, Guo Changsheng, Wang Gang, Wu Wei, Xu Jian
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China; State Environmental Protection Key Laboratory of Ecological Effect and Risk Assessment of Chemicals, Chinese Research Academy of Environmental Sciences, Beijing 100012, China; Center for Environmental Health Risk Assessment and Research, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
Department of Otolaryngology, Strategic Support Force Medical Center, Beijing 100005, China; State Environmental Protection Key Laboratory of Environmental Sense Organ Stress and Health, Beijing 100005, China.
Sci Total Environ. 2022 May 15;821:152960. doi: 10.1016/j.scitotenv.2022.152960. Epub 2022 Jan 10.
Mounting evidence indicated the associations between air pollution and outpatient visits for allergic rhinitis (AR), while few studies assessed the effect modification of these associations by ambient temperature and relative humidity (RH). In this study, dataset of AR outpatients was obtained from Chinese People's Liberation Army Strategic Support Force Characteristic Medical Center in Beijing during 2014 to 2019, and the average concentrations of air pollutants including particulate matter ≤2.5 μm in diameter (PM) and ≤10 μm (PM), nitrogen dioxide (NO), sulfur dioxide (SO), and meteorological factors (temperature and RH) at the same period were collected from one nearby air monitoring station. We performed a time-series study with Poisson regression model to examine the effects of air pollutants on AR outpatients after adjustment for potential confounders. And the effects modification analysis was further conducted by stratifying temperature and RH by tertiles into three groups of low, middle and high. In total of 33,599 outpatient visits for AR were recorded during the study period. Results found that a 10 μg/m increase in PM, PM, NO and SO was associated with significant increases in AR outpatients of 1.24% (95% confidence interval (CI): 0.69%, 1.78%), 0.79% (95% CI: 0.43%, 1.15%), 3.05% (95% CI: 1.72%, 4.40%) and 5.01% (95% CI: 1.18%, 8.96%), respectively. Stronger associations were observed in males than those in females, as well as in young adults (18-44 years) than those in other age groups. Air pollution effects on AR outpatients increased markedly at low temperature (<33.3th percentile) and high RH (>66.7th percentile). Findings in this study indicate that air pollution is associated with increased risk of AR outpatients, and the effects of air pollution on AR could be enhanced at low temperature and high RH.
越来越多的证据表明空气污染与过敏性鼻炎（AR）门诊就诊之间存在关联，而很少有研究评估环境温度和相对湿度（RH）对这些关联的效应修正作用。在本研究中，获取了2014年至2019年期间北京中国人民解放军战略支援部队特色医学中心AR门诊患者的数据，并从附近一个空气监测站收集了同期空气污染物的平均浓度，包括直径≤2.5μm的颗粒物（PM）和≤10μm的颗粒物（PM）、二氧化氮（NO）、二氧化硫（SO）以及气象因素（温度和RH）。我们采用泊松回归模型进行时间序列研究，以在调整潜在混杂因素后检验空气污染物对AR门诊患者的影响。并通过将温度和RH按三分位数分层为低、中、高三组进一步进行效应修正分析。研究期间共记录了33599例AR门诊就诊病例。结果发现，PM、PM、NO和SO每增加10μg/m，AR门诊患者分别显著增加1.24%（95%置信区间（CI）：0.69%，1.78%）、0.79%（95%CI：0.43%，1.15%）、3.05%（95%CI：1.72%，4.40%）和5.01%（95%CI：1.
