Key Laboratory Modern Preparation of CM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang, China.
Nat Prod Res. 2022 Nov;36(21):5553-5558. doi: 10.1080/14786419.2021.2021201. Epub 2021 Dec 29.
A new lignan, named (8, 8')-2,2',3,3'-tetramethoxy-4'-hydroxy-epoxylignan-4---D-glucoside (), together with eight known compounds (-), was isolated from the leaves of . . Their structures were elucidated on the basis of spectral characteristics and comparison with the data of literatures. Besides, the absolute configuration of was established by using ECD calculations. The cytotoxicity of in against three selected tumor cell lines (A549, HeLa and MCF-7) was evaluated by MTT assay. The results showed that compound exhibited moderate cytotoxicity against HeLa cell with IC value of 19.30 ± 4.46 μM.
从... 的叶子中分离得到一个新的木脂素，命名为（8, 8'）-2,2',3,3'-四甲氧基-4'-羟基-环氧木脂素-4---D-葡萄糖苷（），以及八个已知化合物（-）。基于光谱特征和与文献数据的比较，确定了它们的结构。此外，通过ECD 计算确定了的绝对构型。通过 MTT 测定评估了在三种选定的肿瘤细胞系（A549、HeLa 和 MCF-7）中对的细胞毒性。结果表明，化合物对 HeLa 细胞具有中等的细胞毒性，IC 值为 19.30±4.46μM。
