Department of Pharmaceutical Chemistry, Beijing Institute of Radition Medicine, Beijng, China.
School of pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.
Nat Prod Res. 2022 Aug;36(15):3779-3785. doi: 10.1080/14786419.2021.1886100. Epub 2021 Mar 7.
A new lignan derivative, 11-deoxykompasinol A (), together with six known compounds, including five lignan glycosides () and a jasmonic acid derivative (), were isolated from the seeds of . Structure of the new compound was elucidated on the basis of extensive spectroscopic techniques and ECD (electronic circular dichroism calculations). Since most komasinol derivatives were isolated as racemate, the absolute configuration of this type of compound was reported for the first time. The known compounds were identified by comparison with data reported in the literature. All compounds were tested for their cytotoxic activities against the Hela and HepG2 cell lines . The new compound exhibited obvious cytotoxicity against the two cell lines with IC values of 9.43 and 18.26 μM, respectively. Compounds and were found to possess moderate cytotoxicity against the above cell lines.
一种新的木脂素衍生物,11-去氧 kompasinol A (),与六种已知化合物一起,包括五种木脂素糖苷 () 和一种茉莉酸衍生物 (),从 的种子中分离出来。根据广泛的光谱技术和 ECD(电子圆二色性计算),新化合物的结构得以阐明。由于大多数 komasinol 衍生物作为外消旋体分离,该类型化合物的绝对构型被首次报道。已知的化合物通过与文献中报道的数据进行比较来鉴定。所有化合物都进行了对 Hela 和 HepG2 细胞系的细胞毒性活性测试。新化合物 对这两种细胞系表现出明显的细胞毒性,IC 值分别为 9.43 和 18.26 μM。化合物 和 对上述细胞系表现出中等的细胞毒性。