Departamento de Química Orgánica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, México.
Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, México.
Nat Prod Res. 2022 Nov;36(22):5813-5816. doi: 10.1080/14786419.2021.2017931. Epub 2021 Dec 28.
The antinociceptive activity of the ethanolic extract of DC. (EETx) was investigated using the acetic acid-induced writhing and the hot-plate tests in mice. In the acetic acid-induced writhing test, mice treated with EETx (50, 100 and 200 mg/kg, p.o.) exhibited reduced writhing (38%, 67%, and 74%, respectively). In the hot-plate test, the three doses administrated increased the nociceptive response time. The phytochemical analysis of EETx led to the isolation of three known compounds, hygric acid (), 5,6-Dihydroxy-7,8,4'-trimethoxyflavone () and xanthomicrol (). Compound was identified for the first time in this species. These results demonstrate that has potential central and peripheral antinociceptive effects and support the ethnomedicinal use of this plant.
采用醋酸扭体法和热板法，研究了 DC 的乙醇提取物（EETx）的镇痛活性。在醋酸扭体试验中，EETx（50、100 和 200mg/kg，po）处理的小鼠扭体次数减少（分别为 38%、67%和 74%）。在热板试验中，这三个剂量均能增加痛觉反应时间。EETx 的植物化学分析导致了三种已知化合物的分离，分别为 hygric acid ()、5,6-二羟基-7,8,4'-三甲氧基黄酮 () 和 xanthomicrol ()。化合物 是首次在该种植物中发现。这些结果表明 具有潜在的中枢和外周镇痛作用，支持该植物的民族医学用途。
