Ramezani M, Hosseinzadeh H, Daneshmand N
Faculty of Pharmacy, Mashhad University of Medical Sciences, P.O. Box 91775-1365, I.R., Mashhad, Iran.
Fitoterapia. 2001 Mar;72(3):255-62. doi: 10.1016/s0367-326x(00)00290-2.
The antinociceptive effect of different Elaeagnus angustifolia fruit seed extractives was studied in mice using hot-plate and writhing tests. Following intraperitoneal injection, the decoction (EaDE), the ethanol extract (EaEE), the aqueous and n-butanol fractions (EaAF, and EaBF, respectively) of a polyphenolic fraction, and two flavonoid-enriched fractions of EaBF (EaBCF1 and EaBCF2) showed significant antinociceptive activity in both tests, markedly and dose-dependently increasing the pain threshold.
采用热板法和扭体法，在小鼠中研究了不同沙枣果实种子提取物的抗伤害感受作用。腹腔注射后，水煎剂（EaDE）、乙醇提取物（EaEE）、多酚组分的水相和正丁醇相（分别为EaAF和EaBF）以及EaBF的两个富含黄酮的组分（EaBCF1和EaBCF2）在两种试验中均显示出显著的抗伤害感受活性，明显且剂量依赖性地提高了痛阈。
