Laboratory of Physiology, Institute of Biomedical Sciences, Federal University of Alfenas-MG, Brazil.
J Ethnopharmacol. 2011 Mar 24;134(2):348-53. doi: 10.1016/j.jep.2010.12.028. Epub 2010 Dec 24.
Emilia sonchifolia (L.) DC. (Asteraceae) is a medicinal plant traditionally used in Brazilian folk medicine to treat asthma, fever, cuts, wounds and rheumatism. This study was conducted to establish the antinociceptive properties of hydroethanolic extract from aerial parts of Emilia sonchifolia in mice using chemical and thermal models of nociception.
To evaluate the antinociceptive effect of Emilia sonchifolia hydroethanolic extract (EsHE) administered by oral route, peripheral (acetic acid-induced abdominal writhing and formalin), spinal (tail flick) and supra-spinal (hot plate) behavioral models of acute pain were used. High-performance liquid chromatography (HPLC) was used to determine the fingerprint chromatogram of the EsHE.
The EsHE at test doses of 100 and 300 mg/kg, p.o. clearly demonstrated antinociceptive activity in all tests. The extract had a stronger antinociceptive effect than morphine. Administration of the opioid receptor antagonist, naloxone, completely inhibited the antinociceptive effect induced by EsHE (100mg/kg). The presence of phenolic compounds in the extract of Emilia sonchifolia was confirmed using HPLC.
The extract of Emilia sonchifolia markedly exhibits opioid-mediated anti-nociceptive activity action in mice. Thus, may be useful in the treatment of inflammatory hyperalgesic disorders, which supports previous claims of its traditional use.
Emilia sonchifolia（L.）DC.（菊科）是一种药用植物，在巴西民间医学中传统上用于治疗哮喘、发热、切割伤、创伤和风湿病。本研究旨在通过化学和热疼痛模型，确定 Emilia sonchifolia 地上部分水醇提取物在小鼠中的镇痛特性。
为了评估 Emilia sonchifolia 水醇提取物（EsHE）经口服给药的镇痛作用，我们使用了外周（醋酸诱导的腹部扭曲和福马林）、脊髓（尾巴闪烁）和脊髓上（热板）急性疼痛行为模型。高效液相色谱法（HPLC）用于确定 EsHE 的指纹图谱。
在所有测试中，测试剂量为 100 和 300mg/kg 的 EsHE 均表现出明显的镇痛活性。与吗啡相比，该提取物具有更强的镇痛作用。阿片受体拮抗剂纳洛酮的给药完全抑制了 EsHE（100mg/kg）诱导的镇痛作用。使用 HPLC 证实了 Emilia sonchifolia 提取物中存在酚类化合物。
Emilia sonchifolia 的提取物在小鼠中明显表现出阿片样物质介导的镇痛活性。因此，它可能对治疗炎症性痛觉过敏障碍有用，这支持了其传统用途的说法。
