Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada, H3A 1G1.
Department of Civil & Mineral Engineering, University of Toronto, Toronto, Canada, M5S 1A4.
Environ Sci Technol. 2022 Jun 7;56(11):7256-7265. doi: 10.1021/acs.est.1c05364. Epub 2021 Dec 29.
There is growing interest to move beyond fine particle mass concentrations (PM) when evaluating the population health impacts of outdoor air pollution. However, few exposure models are currently available to support such analyses. In this study, we conducted large-scale monitoring campaigns across Montreal and Toronto, Canada during summer 2018 and winter 2019 and developed models to predict spatial variations in (1) the ability of PM to generate reactive oxygen species in the lung fluid (ROS), (2) PM oxidative potential based on the depletion of ascorbate (OP) and glutathione (OP) in a cell-free assay, and (3) anhysteretic magnetic remanence () as an indicator of magnetite nanoparticles. We also examined how exposure to PM oxidative capacity metrics (ROS/OP) varied by socioeconomic status within each city. In Montreal, areas with higher material deprivation, indicating lower area-level average household income and employment, were exposed to PM characterized by higher ROS and OP. This relationship was not observed in Toronto. The developed models will be used in epidemiologic studies to assess the health effects of exposure to PM and iron-rich magnetic nanoparticles in Toronto and Montreal.
当评估室外空气污染对人口健康的影响时，人们越来越有兴趣超越细颗粒物质量浓度 (PM)。然而，目前几乎没有可用的暴露模型来支持此类分析。在这项研究中，我们在 2018 年夏季和 2019 年冬季在加拿大的蒙特利尔和多伦多进行了大规模监测活动，并开发了模型来预测以下方面的空间变化：(1) PM 在肺液中产生活性氧物质 (ROS) 的能力；(2) 在无定形磁剩磁 () 作为磁铁矿纳米颗粒的指标的情况下，基于细胞外测定中抗坏血酸 (ASC) 和谷胱甘肽 (GSH) 耗竭的 PM 氧化潜能；(3)。我们还研究了在每个城市内，PM 氧化能力指标 (ROS/OP) 的暴露如何因社会经济地位而异。在蒙特利尔，物质匮乏程度较高的地区，表明平均家庭收入和就业水平较低，暴露于 ROS 和 OP 较高的 PM 中。在多伦多没有观察到这种关系。开发的模型将用于流行病学研究，以评估在多伦多和蒙特利尔暴露于 PM 和富含铁的磁性纳米颗粒对健康的影响。
