Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada.
Air Health Science Division, Health Canada, Ottawa, Canada.
Environ Health Perspect. 2021 Oct;129(10):107005. doi: 10.1289/EHP9449. Epub 2021 Oct 13.
We do not currently understand how spatiotemporal variations in the composition of fine particulate air pollution [fine particulate matter with aerodynamic diameter ()] affects population health risks. However, recent evidence suggests that joint concentrations of transition metals and sulfate may influence the oxidative potential (OP) of and associated health impacts.
The purpose of the study was to evaluate how of transition metals/OP and sulfur content in outdoor influence associations with acute cardiovascular events.
We conducted a national case-crossover study of outdoor and acute cardiovascular events in Canada between 2016 and 2017 (93,344 adult cases). Monthly mean transition metal and sulfur (S) concentrations in were determined prospectively along with estimates of OP using acellular assays for glutathione (), ascorbate (), and dithiothreitol depletion (). Conditional logistic regression models were used to estimate odds ratios (OR) [95% confidence intervals (CI)] for across strata of transition metals/OP and sulfur.
Among men, the magnitudes of observed associations were strongest when transition metal and sulfur content were elevated. For example, an OR of 1.078 (95% CI: 1.049, 1.108) (per ) was observed for cardiovascular events in men when both copper and S were above the median, whereas a weaker association was observed when both elements were below median values (, 95% CI: 1.007, 1.031). A similar pattern was observed for OP metrics. was not associated with acute cardiovascular events in women.
The transition metal and sulfur content of outdoor influences the strength of association with acute cardiovascular events in men. Regions with elevated concentrations of sulfur and transition metals in should be examined as priority areas for regulatory interventions. https://doi.org/10.1289/EHP9449.
我们目前还不清楚细颗粒物空气污染（空气动力学直径小于等于 2.5 微米的颗粒物）组成在时空上的变化如何影响人口健康风险。然而，最近的证据表明，过渡金属和硫酸盐的联合浓度可能会影响细颗粒物的氧化潜力（OP）及其相关的健康影响。
本研究旨在评估室外细颗粒物中的过渡金属/OP 和硫含量如何影响与急性心血管事件的关联。
我们进行了一项加拿大 2016 年至 2017 年期间户外细颗粒物与急性心血管事件的全国病例交叉研究（93344 例成人病例）。前瞻性地测定了细颗粒物中过渡金属和硫（S）的月均浓度，并使用细胞外谷胱甘肽（）、抗坏血酸（）和二硫苏糖醇耗竭（）的非细胞测定法来估计 OP。使用条件逻辑回归模型来估计各过渡金属/OP 和硫浓度分层下的比值比（OR）[95%置信区间（CI）]。
在男性中，当过渡金属和硫含量升高时，观察到的关联幅度最大。例如，当铜和 S 均高于中位数时，男性心血管事件的 OR 为 1.078（95%CI：1.049，1.108）（每增加 1 ），而当这两个元素均低于中位数时，观察到的关联较弱（OR=1.007，95%CI：1.031）。OP 指标也呈现出类似的模式。女性的细颗粒物与急性心血管事件无关。
户外细颗粒物中的过渡金属和硫含量影响了其与男性急性心血管事件的关联强度。应将过渡金属和硫浓度升高的地区作为监管干预的优先区域进行检查。
Zotero 插件
