过渡金属、添加剂和无溶剂条件下，RCF-亚胺基硫鎓叶立德与环丙烯酮的[3 + 3]环化反应制备多功能化CF-吡啶酮
Transition-Metal-, Additive-, and Solvent-Free [3 + 3] Annulation of RCF-Imidoyl Sulfoxonium Ylides with Cyclopropenones to Give Multifunctionalized CF-Pyridones.
作者信息
Wen Si, Chen Yanhui, Tian Qingyu, Zhang Yuqing, Cheng Guolin
机构信息
Xiamen Key Laboratory of Optoelectronic Materials and Advanced Manufacturing, College of Materials Science and Engineering, the Instrumental Analysis Center, Huaqiao University, Xiamen 361021, China.
出版信息
J Org Chem. 2022 Jan 21;87(2):1124-1132. doi: 10.1021/acs.joc.1c02464. Epub 2021 Dec 29.
An efficient and practical strategy was developed to synthesize 1,3,4-triaryl-6-trifluoromethylpyridones from CF-imidoyl sulfoxonium ylides and cyclopropenones in good to excellent yields. This stepwise [3 + 3] annulation reaction was carried out under transition-metal-, additive-, and solvent-free conditions, generating 1 equiv of dimethyl sulfoxide as byproduct and tolerating a series of functional groups.
开发了一种高效实用的策略，以良好至优异的产率从CF-亚胺基硫鎓叶立德和环丙烯酮合成1,3,4-三芳基-6-三氟甲基吡啶酮。这种逐步的[3 + 3]环化反应在无过渡金属、无添加剂和无溶剂的条件下进行，生成1当量的二甲基亚砜作为副产物，并能耐受一系列官能团。
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