Yang Zuguang, Tang Jianhua, Chen Zhengkai, Wu Xiao-Feng
Department of Chemistry, Key Laboratory of Surface and Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, China.
Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning 116023, China.
Org Lett. 2022 Oct 14;24(40):7288-7293. doi: 10.1021/acs.orglett.2c02685. Epub 2022 Oct 4.
A ruthenium-catalyzed -selective C-H activation and annulation of 1-naphthols with CF-substituted imidoyl sulfoxonium ylides that uses hydroxyl as a weakly coordinating directing group is disclosed. The strategy provides a facile and practical route to diverse trifluoromethyl-containing 2,3-dihydrobenzo[]chromen-2-amines with high efficiency. Notable advantages of this protocol include readily available materials, excellent regioselectivity, good functional group compatibility, and scalability.
公开了一种钌催化的、以羟基作为弱配位导向基团的1-萘酚与CF-取代的亚胺基硫鎓叶立德的 -选择性C-H活化和环化反应。该策略提供了一条简便实用的路线，能够高效地合成各种含三氟甲基的2,3-二氢苯并[]色烯-2-胺。该方法的显著优点包括原料易得、区域选择性优异、官能团兼容性好以及可扩展性强。
