State Key Laboratory of Component-based Chinese Medicine, Haihe Laboratory of Modern Chinese Medicine, College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyang Lake Road, West Zone of Tuanbo New City, Jinghai District, Tianjin 301617, People's Republic of China.
Military Medicine Section, Logistics University of Chinese People's Armed Police Force, 1 Huizhihuan Road, Dongli District, Tianjin 300309, People's Republic of China.
Nanotechnology. 2022 Jan 24;33(16). doi: 10.1088/1361-6528/ac46d5.
Nanomedicine and aptamer have excellent potential in giving play to passive and active targeting respectively, which are considered to be effective strategies in the retro-ocular drug delivery system. The presence of closely adjoined tissue structures in the eye makes it difficult to administer the drug in the posterior segment of the eye. The application of nanomedicine could represent a new avenue for the treatment, since it could improve penetration, achieve targeted release, and improve bioavailability. Additionally, a novel type of targeted molecule aptamer with identical objective was proposed. As an emerging molecule, aptamer shows the advantages of penetration, non-toxicity, and high biocompatibility, which make it suitable for ocular drug administration. The purpose of this paper is to summarize the recent studies on the effectiveness of nanoparticles as a drug delivery to the posterior segment of the eye. This paper also creatively looks forward to the possibility of the combined application of nanocarriers and aptamers as a new method of targeted drug delivery system in the field of post-ophthalmic therapy.
纳米医学和适体在发挥被动和主动靶向作用方面具有优异的潜力，被认为是眼后段药物传递系统的有效策略。眼睛中紧密相邻的组织结构的存在使得难以将药物递送到眼的后段。纳米医学的应用可能代表了一种新的治疗途径，因为它可以提高穿透性、实现靶向释放和提高生物利用度。此外，还提出了一种新型的靶向分子适体，具有相同的目标。作为一种新兴的分子，适体具有穿透性、低毒性和高生物相容性的优点，使其适合眼部药物给药。本文的目的是总结近年来关于纳米颗粒作为眼后段药物传递的有效性的研究。本文还创造性地展望了纳米载体和适体联合应用作为一种新的靶向药物传递系统在眼后治疗领域的可能性。
