Belova A N, Israelyan Yu A, Sushin V O, Shabanova M A, Rezenova A M
Privolzhsky Research Medical University, Nizhny Novgorod, Russia.
Vopr Kurortol Fizioter Lech Fiz Kult. 2021;98(6):61-67. doi: 10.17116/kurort20219806161.
Transcranial photobiomodulation (tPBM) is a form of light therapy that uses monochromatic visible and infrared light from non-ionizing radiation sources (lasers, LEDs) placed on the scalp, forehead, or intranasally to project light directly to target areas of the brain. Accumulated experimental and clinical data indicate the safety and potential efficacy of tPBM in some central nervous system diseases.This article briefly reviews the general concepts of tPBM, the results of experimental and clinical studies on the efficacy of tPBM in Alzheimer's disease, Parkinson's disease, and brain stroke. The possible mechanisms of the tPBM therapeutic effect and the need to choose optimal exposure parameters are discussed. Although the evidence base regarding the efficacy of tPBM in neurodegenerative and vascular brain diseases is still insufficient, analysis of the published data justifies considering tPBM as a promising method of adjuvant therapy for some central nervous system diseases.
经颅光生物调节疗法（tPBM）是一种光疗形式，它利用放置在头皮、前额或鼻腔内的非电离辐射源（激光、发光二极管）发出的单色可见光和红外光，将光线直接投射到大脑的目标区域。累积的实验和临床数据表明，tPBM在某些中枢神经系统疾病中具有安全性和潜在疗效。本文简要回顾了tPBM的一般概念，以及tPBM在阿尔茨海默病、帕金森病和脑卒中等疾病疗效方面的实验和临床研究结果。讨论了tPBM治疗效果的可能机制以及选择最佳照射参数的必要性。尽管关于tPBM在神经退行性和血管性脑疾病中疗效的证据基础仍然不足，但对已发表数据的分析证明，可将tPBM视为某些中枢神经系统疾病辅助治疗的一种有前景的方法。
