Department of Molecular Biology, Harold C. Simmons Comprehensive Cancer, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Department of Molecular Biology, Harold C. Simmons Comprehensive Cancer, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas
Mol Pharmacol. 2022 Apr;101(4):181-190. doi: 10.1124/molpharm.121.000302. Epub 2021 Dec 28.
The mammalian target of rapamycin (mTOR) senses upstream stimuli to regulate numerous cellular functions such as metabolism, growth, and autophagy. Increased activation of mTOR complex 1 (mTORC1) is typically observed in human disease and continues to be an important therapeutic target. Understanding the upstream regulators of mTORC1 will provide a crucial link in targeting hyperactivated mTORC1 in human disease. In this mini-review, we will discuss the regulation of mTORC1 by upstream stimuli, with a specific focus on G-protein coupled receptor signaling to mTORC1. SIGNIFICANCE STATEMENT: mTORC1 is a master regulator of many cellular processes and is often hyperactivated in human disease. Therefore, understanding the molecular underpinnings of G-protein coupled receptor signaling to mTORC1 will undoubtedly be beneficial for human disease.
哺乳动物雷帕霉素靶蛋白（mTOR）感知上游刺激，调节多种细胞功能，如代谢、生长和自噬。mTOR 复合物 1（mTORC1）的过度激活通常在人类疾病中观察到，并且仍然是一个重要的治疗靶点。了解 mTORC1 的上游调节剂将为靶向人类疾病中过度激活的 mTORC1 提供关键联系。在这篇迷你综述中，我们将讨论上游刺激对 mTORC1 的调节，特别关注 G 蛋白偶联受体信号对 mTORC1 的调节。
mTORC1 是许多细胞过程的主要调节剂，在人类疾病中通常过度激活。因此，了解 G 蛋白偶联受体信号对 mTORC1 的分子基础无疑将有益于人类疾病。
