Dos Santos-Silva Carlos André, Tricarico Paola Maura, Vilela Lívia Maria Batista, Roldan-Filho Ricardo Salas, Amador Vinícius Costa, d'Adamo Adamo Pio, Rêgo Mireli de Santana, Benko-Iseppon Ana Maria, Crovella Sergio
Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy.
Departamento de Genética, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Brazil.
Front Microbiol. 2021 Dec 13;12:795217. doi: 10.3389/fmicb.2021.795217. eCollection 2021.
Among chronic skin autoinflammatory diseases, Hidradenitis Suppurativa (HS) stands out for its chronicity, highly variable condition, and profound impact on the patients' quality of life. HS is characterized by suppurative skin lesions in diverse body areas, including deep-seated painful nodules, abscesses, draining sinus, and bridged scars, among others, with typical topography. To date, HS is considered a refractory disease and medical treatments aim to reduce the incidence, the infection, and the pain of the lesions. For this purpose, different classes of drugs, including anti-inflammatory molecules, antibiotics and biological drugs are being used. Antimicrobial peptides (AMPs), also called defense peptides, emerge as a new class of therapeutic compounds, with broad-spectrum antimicrobial action, in addition to reports on their anti-inflammatory, healing, and immunomodulating activity. Such peptides are present in prokaryotes and eukaryotes, as part of the innate eukaryotic immune system. It has been proposed that a deregulation in the expression of AMPs in human epithelial tissues of HS patients may be associated with the etiology of this skin disease. In this scenario, plant AMPs stand out for their richness, diversity of types, and broad antimicrobial effects, with potential application for topical systemic use in patients affected by HS.
在慢性皮肤自身炎症性疾病中，化脓性汗腺炎（HS）因其慢性病程、高度可变的病情以及对患者生活质量的深远影响而备受关注。HS的特征是在身体不同部位出现化脓性皮肤病变，包括深部疼痛性结节、脓肿、引流窦道和桥状瘢痕等，具有典型的形态分布。迄今为止，HS被认为是一种难治性疾病，医学治疗旨在降低病变的发生率、感染率和疼痛程度。为此，正在使用不同类别的药物，包括抗炎分子、抗生素和生物药物。抗菌肽（AMPs），也称为防御肽，作为一类新型治疗化合物出现，具有广谱抗菌作用，此外还有关于其抗炎、愈合和免疫调节活性的报道。这类肽存在于原核生物和真核生物中，是真核生物固有免疫系统的一部分。有人提出，HS患者人类上皮组织中AMPs表达的失调可能与这种皮肤病的病因有关。在这种情况下，植物抗菌肽因其丰富性、类型多样性和广泛的抗菌作用而备受瞩目，具有在HS患者中局部或全身应用的潜力。
