School of Life Science and Technology, China Pharmaceutical University, Nanjing 211100, P.R. China.
School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing 211100, P.R. China.
Nucleic Acids Res. 2022 Jan 7;50(D1):D488-D496. doi: 10.1093/nar/gkab651.
Stapled antimicrobial peptides are an emerging class of artificial cyclic peptide molecules which have antimicrobial activity and potent structure stability. We previously published the Data Repository of Antimicrobial Peptides (DRAMP) as a manually annotated and open-access database of antimicrobial peptides (AMPs). In the update of version 3.0, special emphasis was placed on the new development of stapled AMPs, and a subclass of specific AMPs was added to store information on these special chemically modified AMPs. To help design low toxicity AMPs, we also added the cytotoxicity property of AMPs, as well as the expansion of newly discovered AMP data. At present, DRAMP has been expanded and contains 22259 entries (2360 newly added), consisting of 5891 general entries, 16110 patent entries, 77 clinical entries and 181 stapled AMPs. A total of 263 entries have predicted structures, and more than 300 general entries have links to experimentally determined structures in the Protein Data Bank. The update also covers new annotations, statistics, categories, functions and download links. DRAMP is available online at http://dramp.cpu-bioinfor.org/.
订书钉抗菌肽是一类新兴的人工环肽分子，具有抗菌活性和很强的结构稳定性。我们之前发布了抗菌肽数据库 (DRAMP)，这是一个人工注释和开放获取的抗菌肽 (AMP) 数据库。在版本 3.0 的更新中，特别强调了订书钉 AMP 的新发展，并添加了一个特定 AMP 的子类，以存储有关这些特殊化学修饰 AMP 的信息。为了帮助设计低毒性 AMP，我们还添加了 AMP 的细胞毒性特性，以及新发现的 AMP 数据的扩展。目前，DRAMP 已经扩展，包含 22259 条记录（新添加 2360 条），其中包括 5891 条一般记录、16110 条专利记录、77 条临床记录和 181 条订书钉 AMP。共有 263 条记录具有预测结构，并且超过 300 条一般记录与蛋白质数据库中的实验确定结构有链接。更新还涵盖了新的注释、统计数据、类别、功能和下载链接。DRAMP 可在线获取，网址为 http://dramp.cpu-bioinfor.org/。
