Department of Psychiatry, University of Sao Paulo Medical School, Sao Paulo, SP, Brazil.
Department of Psychiatry, University of Toronto, Toronto, Canada.
J Neural Transm (Vienna). 2022 Jan;129(1):95-103. doi: 10.1007/s00702-021-02455-4. Epub 2021 Dec 29.
Bipolar disorder shares symptoms and pathological pathways with other neurodegenerative diseases, including frontotemporal dementia (FTD). Since TAR DNA-binding protein 43 (TDP-43) is a neuropathological marker of frontotemporal dementia and it is involved in synaptic transmission, we explored the role of TDP-43 as a molecular feature of bipolar disorder (BD). Homogenates were acquired from frozen hippocampus of postmortem brains of bipolar disorder subjects. TDP-43 levels were quantified using an ELISA-sandwich method and compared between the postmortem brains of bipolar disorder subjects and age-matched control group. We found higher levels of TDP-43 protein in the hippocampus of BD (n = 15) subjects, when compared to controls (n = 15). We did not find associations of TDP-43 with age at death, postmortem interval, or age of disease onset. Our results suggest that protein TDP-43 may be potentially implicated in behavioral abnormalities seen in BD. Further investigation is needed to validate these findings and to examine the role of this protein during the disease course and mood states.
双相情感障碍与其他神经退行性疾病（包括额颞叶痴呆）共享症状和病理途径。由于 TAR DNA 结合蛋白 43（TDP-43）是额颞叶痴呆的神经病理学标志物，并且它参与突触传递，因此我们探讨了 TDP-43 作为双相情感障碍（BD）分子特征的作用。从死后大脑冷冻海马体中获取匀浆。使用 ELISA 夹心法定量 TDP-43 水平，并在双相情感障碍受试者的死后大脑与年龄匹配的对照组之间进行比较。与对照组（n=15）相比，我们发现 BD（n=15）受试者海马体中的 TDP-43 蛋白水平更高。我们没有发现 TDP-43 与死亡年龄、死后间隔或发病年龄之间的关联。我们的结果表明，蛋白质 TDP-43 可能与 BD 中观察到的行为异常有关。需要进一步的研究来验证这些发现，并检查该蛋白在疾病过程和情绪状态中的作用。
