Department of Psychiatry & Behavioral Science, Juntendo Graduate School of Medicine, Tokyo, Japan.
Department of Psychiatry & Behavioral Science, Juntendo Graduate School of Medicine, Tokyo, Japan; Juntendo University Mood Disorder Project (JUMP), Department of Psychiatry, Juntendo Koshigaya Hospital, 560 Fukuroyama, Koshigaya, Saitama, Japan.
J Affect Disord. 2019 May 1;250:284-288. doi: 10.1016/j.jad.2019.03.024. Epub 2019 Mar 7.
Recent reports have suggested a relationship between affective disorder including depression and bipolar disorder (BP) and frontotemporal dementia (FTD). TAR DNA binding protein (TDP) -43 is a protein found in the brain and peripheral fluid of patients with FTD. To examine a possible association between affective disorders and FTD, serum levels of TDP-43 were evaluated in late-life patients with major depressive episode (MDE).
The subjects were 74 late-life (≥50 years old) inpatients with DSM-IV or -5 MDE (58 had major depressive disorders and 16 had BP) and 58 healthy subjects. Patients were recruited from Juntendo Koshigaya Hospital, Saitama, Japan, between January 2005 and May 2017. Serum TDP-43 levels were measured using an ELISA kit.
Serum levels of TDP-43 were significantly higher in the MDE group than the control group independent of age and sex.
All patients were on antidepressant medication.
Our finding suggests that some depressive patients may be in a prodromal stage of FTD or very-early stage of FTD comorbid with depression.
最近的报告表明，情感障碍（包括抑郁症和双相情感障碍）与额颞叶痴呆（FTD）之间存在关联。 TAR DNA 结合蛋白（TDP）-43 是一种存在于 FTD 患者大脑和外周体液中的蛋白质。为了研究情感障碍与 FTD 之间可能存在的关联，我们评估了老年期单相抑郁发作（MDE）患者血清中 TDP-43 的水平。
本研究纳入了 74 名年龄≥50 岁（老年）的 DSM-IV 或 -5 MDE 住院患者（58 名患有单相抑郁障碍，16 名患有双相情感障碍）和 58 名健康对照者。这些患者均来自日本埼玉县的顺天堂大学医院，研究时间为 2005 年 1 月至 2017 年 5 月。使用 ELISA 试剂盒检测血清 TDP-43 水平。
不论年龄和性别，MDE 组的血清 TDP-43 水平明显高于对照组。
所有患者均在服用抗抑郁药。
我们的发现提示，一些抑郁患者可能处于 FTD 的前驱期或与抑郁共病的 FTD 早期阶段。
