Jahn S, Krohm P, Volk H D, Kiessig S, Grunow R, von Baehr R
Z Gesamte Inn Med. 1987 Mar 15;42(6):160-3.
The influence of steroids on lymphocyte responses was tested in vitro. The inhibition of early events of lymphocyte stimulation and cell proliferation after PHA stimulation was estimated. We found, however, different individual responses of immune cells of various donors to the preparations dexamethasone, prednisolone, hydrocortisone or methylprednisolone in both in vitro models tested. Steroid treatment of lymphocyte cultures resulted in both inhibition and enhancement of PWM-driven Ig synthesis in cultures derived from different test persons. In experiments with lymphocytes from patients with acute systemic lupus erythematosus we found a dramatically enhanced PWM-stimulated IgG synthesis which is disturbed in cultures of these patients. The individuality of steroid sensitivity of lymphocyte cultures of healthy test persons and the abnormal reactivity of SLE lymphocytes were discussed in relation to therapeutical applications.
在体外测试了类固醇对淋巴细胞反应的影响。评估了PHA刺激后淋巴细胞刺激早期事件和细胞增殖的抑制情况。然而，在两种测试的体外模型中，我们发现不同供体的免疫细胞对地塞米松、泼尼松龙、氢化可的松或甲泼尼龙制剂有不同的个体反应。对淋巴细胞培养物进行类固醇处理后，来自不同测试者的培养物中PWM驱动的Ig合成既有抑制作用，也有增强作用。在对急性系统性红斑狼疮患者的淋巴细胞进行的实验中，我们发现PWM刺激的IgG合成显著增强，而在这些患者的培养物中这种合成受到了干扰。讨论了健康测试者淋巴细胞培养物类固醇敏感性的个体差异以及SLE淋巴细胞的异常反应性与治疗应用的关系。
