Department of Traditional Chinese Medicine, Changchun University of Chinese Medicine, 1035 Boshuo Road, Changchun, Jilin, China.
Department of Cardiology, The Third Affiliated Clinical Hospital of Changchun University of Traditional Chinese Medicine, No. 1643 Jingyue Street, Jingyue High-Tech Development Zone, Changchun, Jilin, China.
Medicine (Baltimore). 2021 Dec 30;100(52):e28450. doi: 10.1097/MD.0000000000028450.
Coronary heart disease (CHD) angina pectoris is a clinical syndrome in which episodic chest pain or chest discomfort is the main manifestation of temporary ischemia and hypoxia of the myocardium due to coronary atherosclerosis and coronary artery functional changes (spasm). A large amount of clinical evidence confirms that acupuncture combined with Chinese herbal medicine in the treatment of CHD and angina pectoris can relieve the symptoms of angina pectoris and improve the performance of electrocardiograph ischemia; It still has obvious therapeutic effects in regulating the levels of cardiovascular regulatory peptides ET and cGRP. To better evaluate the effectiveness and safety of acupuncture combined with Chinese herbal medicine in the treatment of CHD and angina pectoris, we designed a systematic evaluation program to provide a reliable scientific basis for the future use of this method.
Search Pubmed database, Embase, Cochrane library, Chinese Biomedical Literature CD-ROM Database (CBMdisk), China Journal Network Full-text Database (CNKI), Wanfang Database, Web of Science (SCI-E), the retrieval time is established from each database Until October 2021, search for relevant eligible randomized controlled trials with keywords or subject terms "acupuncture", "Chinese herbal medicine", and "CHD angina". Outcome indicators were clinical symptoms of CHD and angina pectoris, changes in electrocardiogram, changes in blood lipids, and significant improvement in traditional Chinese medicine syndromes before and after treatment. Two researchers independently carried out data extraction and quality assessment, and use RevMan5.3 software to carry out final data analysis and assessment.
This study provides a reliable clinical scientific basis for acupuncture combined with Chinese herbal medicine for the treatment of CHD and angina pectoris.
Acupuncture combined with Chinese herbal medicine can effectively relieve the clinical symptoms of CHD and angina pectoris and improve the performance of electrocardiograph. At the same time, it can reduce the cardiovascular regulatory peptide ET and increase the level of cGRP in the patient's plasma, thus confirming its effectiveness and safety.
冠心病心绞痛是一种临床综合征，其特征是由于冠状动脉粥样硬化和冠状动脉功能变化（痉挛）导致心肌暂时缺血和缺氧而出现间歇性胸痛或胸部不适。大量临床证据证实，针刺结合中药治疗冠心病心绞痛能缓解心绞痛症状，改善心电图缺血程度；对调节心血管调节肽 ET 和 cGRP 水平仍有明显的治疗作用。为了更好地评估针刺结合中药治疗冠心病心绞痛的有效性和安全性，我们设计了一个系统评价方案，为今后使用这种方法提供可靠的科学依据。
检索 Pubmed 数据库、Embase、 Cochrane 图书馆、中国生物医学文献光盘数据库（CBMdisk）、中国期刊全文数据库（CNKI）、万方数据库、Web of Science（SCI-E），检索时间从每个数据库建立到 2021 年 10 月，检索相关合格的随机对照试验，关键词或主题词为“针刺”、“中药”和“冠心病心绞痛”。结局指标为冠心病心绞痛的临床症状、心电图变化、血脂变化及治疗前后中医证候的显著改善。两名研究人员独立进行数据提取和质量评估，并使用 RevMan5.3 软件进行最终数据分析和评估。
本研究为针刺结合中药治疗冠心病心绞痛提供了可靠的临床科学依据。
针刺结合中药能有效缓解冠心病心绞痛的临床症状，改善心电图表现。同时能降低患者血浆中心血管调节肽 ET 水平，提高 cGRP 水平，证实其有效性和安全性。
