Altınova Alev Eroğlu
Gazi University Faculty of Medicine, Department of Endocrinology and Metabolism, 06500 Ankara, Turkey.
J Clin Endocrinol Metab. 2022 Apr 19;107(5):e1778-e1788. doi: 10.1210/clinem/dgab921.
Beige adipocyte, the third and relatively new type of adipocyte, can emerge in white adipose tissue (WAT) under thermogenic stimulations that is termed as browning of WAT. Recent studies suggest that browning of WAT deserves more attention and therapies targeting browning of WAT can be helpful for reducing obesity. Beyond the major inducers of browning, namely cold and β 3-adrenergic stimulation, beige adipocytes are affected by several factors, and excess adiposity per se may also influence the browning process. The objective of the present review is to provide an overview of recent clinical and preclinical studies on the hormonal and nonhormonal factors that affect the browning of WAT. This review further focuses on the role of obesity per se on browning process.
米色脂肪细胞是第三种且相对较新的脂肪细胞类型，在产热刺激下可出现在白色脂肪组织（WAT）中，这一过程被称为WAT的褐变。最近的研究表明，WAT的褐变值得更多关注，针对WAT褐变的治疗方法可能有助于减轻肥胖。除了褐变的主要诱导因素，即寒冷和β-3肾上腺素能刺激外，米色脂肪细胞还受到多种因素的影响，而且肥胖本身也可能影响褐变过程。本综述的目的是概述近期关于影响WAT褐变的激素和非激素因素的临床和临床前研究。本综述进一步聚焦肥胖本身在褐变过程中的作用。
