Zhang Zhi-Han, Xu Dan-Yu, Chen Guan-Yuan, Teng Teng, Wu Hong-Yan, Zhou Xin-Yu
Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2023 Mar;54(2):257-262. doi: 10.12182/20230360503.
The intestinal barrier, a complex structure consisting of multiple layers of defense barriers, blocks the transfer of intestinal and foreign bacteria and their metabolites into the internal environment of the human body. Intestinal permeability can be used to evaluate the integrity of the intestinal barrier. Increased intestinal permeability has been observed in patients with depressive disorder. Some studies have reported an interaction between depressive disorder and intestinal barrier. Herein, we reviewed reported findings on the mechanisms of how systematic low-grade inflammation, vagal nerve dysfunction, and hypothalamic-pituitary-adrenal axis dysfunction cause changes in intestinal permeability in patients with depressive disorder and the pathogenic mechanism of how bacterial translocation caused by damaged intestinal barrier leads to depressive disorder. In addition, the potential mechanisms of how antidepressants improve intestinal permeability and how probiotics improve depressive disorder have been discussed.
肠道屏障是一种由多层防御屏障组成的复杂结构，可阻止肠道细菌、外来细菌及其代谢产物进入人体内部环境。肠道通透性可用于评估肠道屏障的完整性。在抑郁症患者中已观察到肠道通透性增加。一些研究报道了抑郁症与肠道屏障之间的相互作用。在此，我们综述了关于系统性低度炎症、迷走神经功能障碍和下丘脑-垂体-肾上腺轴功能障碍如何导致抑郁症患者肠道通透性改变的机制，以及受损肠道屏障引起的细菌易位如何导致抑郁症的致病机制的报道结果。此外，还讨论了抗抑郁药改善肠道通透性以及益生菌改善抑郁症的潜在机制。
