非编码基因组的表观遗传调控：免疫肿瘤学的机遇

Independent Researcher, 28049 Madrid, Spain.

Epigenomes. 2020 Sep 10;4(3):22. doi: 10.3390/epigenomes4030022.

The contribution of the non-coding genome to disease and its therapeutic potential have been largely unexplored. Recently, several epigenetic drugs developed for cancer treatment have been described to mediate therapeutic effects through the reactivation of the expression of transposable elements in cancer cells. This event activates innate immunity-related pathways and promotes the generation of neoantigens in tumor cells, improving the efficacy of immunotherapeutic treatments. This review focuses on the regulation of transposable elements by epigenetic inhibitors and its implications for immuno-oncology.

非编码基因组对疾病的贡献及其治疗潜力在很大程度上尚未得到探索。最近，有报道称几种用于癌症治疗的表观遗传药物可通过重新激活癌细胞中转座元件的表达来介导治疗效果。这一事件激活了与先天免疫相关的信号通路，并促进肿瘤细胞中新抗原的产生，从而提高免疫治疗的疗效。本综述重点关注表观遗传抑制剂对转座元件的调控及其对免疫肿瘤学的影响。